运动干预肥胖症肠道菌群的作用机制研究进展

Research Progress on the Mechanism of Action of Exercise Intervention in Intestinal Flora in Obesity

肠道菌群的稳态是机体健康的前提之一。若肠道菌群失调,则会出现低度、慢性、系统性的炎症。在长期慢性炎症的作用下,会导致机体出现各种代谢性疾病,甚至发展为更严重的疾病。运动作为一种非药物性治疗,从动物实验和人体实验中均可以得到有力的证据,适度运动可以提高肠道菌群丰富度、改善肠道内在结构、减少促炎因子从而发挥菌群的积极调控作用。通过综述运动作为一种外界应激源对机体肠道菌群结构和多样性变化的影响,以及菌群改善肥胖症的作用机制,以期为肥胖的改善和治疗提供新的方法。

The homeostasis of the intestinal flora is one of the prerequisites for the health of the body,if the intestinal flora is imbalanced,it will lead to low-grade,chronic,systemic inflammation,under the action of long-term chronic inflammation,it will lead to various metabolic diseases in the body,and even develop into more serious diseases.As a non-drug treatment,exercise can obtain strong evidence from animal experimental models and human experiments,and appropriate exercise can improve the richness of intestinal flora,improve the intrinsic structure of the intestine,reduce pro-inflammatory factors and play a positive regulatory role in the flora.In this paper,the effects of exercise as an external stressor on the structure and diversity of intestinal flora and the mechanism of action of microbiota in improving obesity are reviewed to provide new methods for improving and treating obesity.