氧化铁医用磁性纳米粒子的制备与表征

Preparation and characterization of medical magnetic nanoparticles containing iron oxide

目的考察氧化铁医用磁性纳米粒子的制备方法和条件,为其在生物医学领域发挥更好的作用提供参考。方法通过控制铁盐浓度、氨水浓度和反应温度对氧化铁纳米粒子的制备条件进行筛选。配制不同浓度(0.25、0.20、0.15 mol/L)的铁盐混合溶液,不同浓度(2.0、1.5、1.0 mol/L)的氨水溶液,在其他条件不变的情况下,控制反应温度(30、40、50℃),检测不同条件下制备的氧化铁纳米粒子粒径及磁性。结果单因素试验结果显示,共沉淀法制备氧化铁纳米粒子时,铁盐混合溶液浓度为0.25 mol/L时产品平均粒径最大,为(20.6±0.2)nm,磁铁吸引距离最长,为(4.06±0.19)cm。控制铁盐混合溶液浓度为0.25 mol/L,其他条件不变,氨水浓度为1.0 mol/L时,制备的粒子磁铁吸引距离最长,为(4.06±0.20)cm。在其他条件最优的前提下,随着反应温度的不断升高,粒子的磁性降低,最佳反应温度为30℃。结论采用共沉淀法制备的氧化铁磁性纳米粒子的最优方案为0.20 mol/L的铁盐溶液、1.0 mol/L的氨水溶液在30℃下反应。

Objective To study the preparation method and condition of medical magnetic nanoparticles containing iron oxide,and provide reference for their better application in the field of biomedical research.Methods The preparation conditions of iron oxide nanoparticles were screened by controlling the concentration of iron salts,ammonia solution and reaction temperature.The mixed solutions of iron salts with different concentration(0.25,0.20 and 0.15 mol/L)and ammonia solutions with different concentration(2.0,1.5 and 1.0 mol/L)were prepared.Under other unchanged conditions,the reaction temperature(30,40 and 50℃)was controlled and the particle size and magnetism of iron oxide nanoparticles prepared under different conditions were detected.Results The results of single factor experiment showed that when preparing iron oxide nanoparticles using co-precipitation method,the average particle size was the highest[(20.6±0.2)nm]at 0.25 mol/L of iron salt solution,and the magnetic attraction distance was the longest[(4.06±0.19)cm].When the concentration of mixed iron salt solution was controlled to 0.25 mol/L and other conditions remained unchanged,and the ammonia concentration was 1.0 mol/L,the prepared particle magnet had the longest attraction distance[(4.06±0.20)cm].Under other optimal conditions,as the reaction temperature continued to increase,the magnetic properties of particles decreased,and the optimal reaction temperature was 30℃.Conclusion The optimal scheme for preparing iron oxide magnetic nanoparticles using co-precipitation method is 0.20 mol/L iron salt solution and 1.0 mol/L ammonia solution at 30℃.