奥美拉唑联合阿莫西林治疗慢性浅表性胃炎的临床效果

Clinical Efficacy of Omeprazole Combined with Amoxicillin in the Treatment of Chronic Superficial Gastritis

目的观察奥美拉唑联合阿莫西林治疗慢性浅表性胃炎的效果。方法选取经胃镜诊断均为慢性浅表性胃炎的患者,均在福清市中医院于2021年8月至2023年1月期间收治,总计100例,采用随机数字表方法分组,对照组(50例,奥美拉唑治疗)和观察组(50例,奥美拉唑+阿莫西林治疗)。结果观察组慢性浅表性胃炎患者临床治疗总有效率高于对照组(P<0.05);观察组慢性浅表性胃炎患者纳差消失时间、恶心呕吐消失时间、腹胀消失时间均短于对照组(均P<0.05);治疗后,观察组慢性浅表性胃炎患者肿瘤坏死因子α、白细胞介素6、核转录因子水平、临床病理积分、疼痛评分均低于对照组(均P<0.05);治疗后,观察组慢性浅表性胃炎患者胃泌素水平低于对照组,胃动素水平高于对照组(均P<0.05);观察组慢性浅表性胃炎患者恶心、呕吐、头晕总不良反应发生率与对照组相近,对比结果差异不显著(P>0.05)。结论奥美拉唑联合阿莫西林治疗慢性浅表性胃炎的效果显著优于奥美拉唑。

Objective To study the effect of omeprazole combined with amoxicillin in the treatment of chronic superficial gastritis.Methods A total of 100 patients diagnosed with chronic superficial gastritis through gastroscopy from August 2021 to January 2023 were selected.They were randomly divided into a control group(50 cases,treated with omeprazole)and an observation group(50 cases,treated with omeprazole and amoxicillin)using a random number table method.Results The total effective rate of clinical treatment of patients with chronic superficial gastritis in the observation group was higher than that of the control group(P<0.05);the time for the disappearance of dyspepsia,the time for the disappearance of nausea and vomiting,and the time for the disappearance of abdominal distension of patients with chronic superficial gastritis in the observation group were shorter than that of the control group(all P<0.05);after the treatment,the levels of tumor necrosis factor alpha,interleukin 6,nuclear transcription factor,clinicopathological scores,and pain score were lower than those of the control group(all P<0.05);after treatment,the gastrin level of patients with chronic superficial gastritis in the observation group was lower than that of the control group,and the gastric actin level was higher than that of the control group(all P<0.05);the incidence of nausea,vomiting and dizziness of patients with chronic superficial gastritis in the observation group was similar to that of the control group,and the difference of the results of the comparison was not significant(P>0.05).Conclusions The efficacy of omeprazole combined with amoxicillin in the treatment of chronic superficial gastritis is significantly better than omeprazole.