温胆汤加减治疗痰热郁结型冠心病的临床疗效观察

Clinical Efficay of Wendan Decoction in Treating Phlegm-Heat Stagnation Coronary Heart Disease

目的观察温胆汤加减治疗痰热郁结型冠心病的临床疗效及安全性。方法纳入合并焦虑症(痰热郁结型)的冠心病患者60例,随机分为中西医结合组30例,西医组30例。西医组患者给予口服给予西药常规治疗加氟哌噻吨美利曲辛片。中西医结合组患者在西医治疗组基础上,联合温胆汤加减,每日2次口服,每次100 ml。两组疗程均为28 d。比较两组治疗的临床疗效和安全性。结果连续治疗28 d后,中西医结合组治疗的临床总有效率90%,高于西医组的76%;中西医结合组中医证候积分明显高于西医组;中西医结合组西雅图心绞痛量表各项评分改善均优于西医组,以上指标比较差异均具有统计学意义(均P<0.05)。两组均未发现明显不良反应。结论对于痰热郁结型冠心病患者,温胆汤加减治疗联合西医常规治疗,相比单纯西医治疗能进一步改善患者心绞痛发作及精神状态,减少心绞痛发作次数,减轻发作程度,且安全性良好。

Objective To observe the clinical efficacy and safety of the addition and subtraction of warm bile soup in the treatment of phlegmheat-stagnation type coronary heart disease.Methods A total of 60 patients with coronary heart disease combined with anxiety disorder(phlegmheat depression type)were included and randomly divided into 30 cases in the combined Chinese and Western medicine group and 30 cases in the Western medicine group.Patients in the western medicine group were given oral administration of conventional western medicine plus haloperidol melittin tablets.In the combined Chinese and western medicine group,patients were treated with warm bile soup,which was administered orally twice a day,100 ml each time,and the duration of treatment was 28 days.The clinical efficacy and safety of the two groups were compared.Results After 28 days of continuous treatment,the total clinical effectiveness rate of the combined Chinese and Western medicine group was 90%,which was higher than that of the Western medicine group(76%);the points of Chinese medicine symptoms in the combined group were significantly higher than those in the Western medicine group;the improvement of all the scores of the Seattle Angina Scale in the combined group was better than that in the Western medicine group,and the differences of the above indexes were statistically significant(all P<0.05).No obvious adverse reactions were found in both groups.Conclusions For patients with phlegm-heat stagnation type coronary heart disease,the combination of warm bile soup and western medicine treatment can further improve the patients'angina attacks and mental status,reduce the number of angina attacks and the degree of attacks,and the safety is good,comparing with the western medicine treatment alone.