细胞焦亡在老年男性良性前列腺增生中的作用综述

Review of the role of pyroptosis in benign prostatic hyperplasia in old males

细胞焦亡是一种新的细胞程序性死亡方式,主要表现为细胞持续肿胀至破裂,进而释放出大量的炎症因子引起炎症反应。良性前列腺增生(benign prostatic hyperplasia,BPH)是老年男性最常发生的泌尿系统疾病,与激素变化和炎症反应密切相关。近年来,细胞焦亡在BPH的发生、发展中的作用引起了人们的关注。该文总结了细胞焦亡的机制,归纳了老年男性BPH的发病机制,并概述了细胞焦亡在BPH中的作用,以期为通过细胞焦亡寻找对BPH更有效的治疗措施提供新的思路。

Pyroptosis,a new mode of programmed cell death,is primarily characterized by persistent cellular swelling that culminates in cell rupture.This process results in the release of large amounts of inflammatory factors,subsequently triggering an inflammatory response.Benign prostatic hyperplasia(BPH)is the most frequent urological disease in old males and is closely associated with changes in hormones and inflammation response.In recent years,the role of pyroptosis in the occurrence and development of BPH has also received increasing attention.This article summarizes the mechanisms of pyroptosis,concludes the pathogenesis associated with BPH in old males,and outlines the role of pyroptosis in BPH,to provide new ideas for finding more effective therapeutic measures for BPH through pyroptosis.