摘要
胶原蛋白是人体含量最丰富的蛋白质之一,是细胞外基质的主要成分。胶原蛋白可以调节细胞行为,胶原蛋白表达失调可导致多种疾病,包括肿瘤。肿瘤中胶原蛋白主要由成纤维细胞产生,在肿瘤进展和转移中发挥重要作用。胶原蛋白作为肿瘤患者预后的预测因子,可能是有效治疗及预防肿瘤进展及转移的靶点,将来可能会研发出针对胶原蛋白及其受体的抗肿瘤药物。该文综述近年来新发现的胶原蛋白在肿瘤发生和发展中的作用,特别是胶原蛋白在维持肿瘤细胞休眠状态和免疫逃逸中的作用,以及胶原蛋白如何参与肿瘤细胞代谢。
Collagen is one of the most abundant proteins in the body and is the main component of the extracellular matrix.Collagen regulates cellular behavior,and its dysregulation can cause a variety of diseases,including cancer.Collagen in tumors is mainly produced by fibroblasts and plays an important role in cancer progression and metastasis.Collagen can act as a prognostic predictor for cancer patients and may be an effective target for the treatment and prevention of tumor progression and metastasis.Anti-tumor drugs targeting collagen and its receptors may be developed in the future.This review focuses on the newly discovered role of collagen in cancer in recent years,specifically the role of collagen in tumor cell dormancy and immune evasion,and the participation of collagen in tumor cell metabolism.
作者
唐雷
徐迎春
张凤春
TANG Lei;XU Yingchun;ZHANG Fengchun(Department of Oncology,Suzhou Kowloon Hospital,Shanghai Jiao Tong University School of Medicine,Suzhou 215021,China;Department of Oncology,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200126,China;Department of Oncology,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China)
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2023年第12期1577-1584,共8页
Journal of Shanghai Jiao tong University:Medical Science
基金
2023年苏州市姑苏卫生人才计划
2023年度苏州市基础研究计划(医学应用基础研究,SKY2023110)
2022年度苏州市科技计划项目(医疗卫生科技创新,SKYD2022083)
2020年度苏州市科技发展计划项目(SYSD2020079,SYSD2020075)。
关键词
胶原蛋白
细胞外基质
癌症进展
肿瘤转移
免疫逃逸
collagen
extracellular matrix
cancer progression
tumor metastasis
immune escape
