围产期炎症因子及氧化应激指标对剖宫产产后抑郁的预测

Prediction of inflammatory factors and oxidative stress indicators for postpartum depression after cesarean section

目的:分析围产期脑脊液与静脉血的炎症因子及氧化应激指标对剖宫产后抑郁症的预测效能。方法:回顾性分析2021年1月至2022年6月焦作市妇幼保健院行剖宫产术治疗的121例患者的临床资料,根据爱丁堡产后抑郁评分(EPDS)结果,将患者分为产后抑郁组70例和对照组51例。比较两组患者围产期脑脊液及静脉血中炎症因子、氧化应激指标的水平,分析上述指标对剖宫产后抑郁症的预测效能。结果:产后抑郁组脑脊液及外周静脉血的肿瘤坏死因子⁃α(TNF⁃α)、白介素⁃6(IL⁃6)、超敏C⁃反应蛋白(hs⁃CRP)和丙二醇(MDA)的水平均高于对照组,而超氧化物歧化酶(SOD)与氧化氢酶(CAT)的水平均低于对照组,以上差异均具有统计学意义(P<0.05)。产后抑郁与炎症因子、促氧化应激因子水平呈正相关,与抗氧化应激因子呈负相关,差异均具有统计学意义(P<0.05)。结论:围产期炎症因子、氧化应激因子变化对剖宫产后抑郁症具有较高预测效能。

Objective:To analyze the predictive effectiveness of inflammatory factors and oxidative stress indicators in perinatal cerebrospinal fluid and venous blood on postpartum depression after cesarean section.Methods:Retrospective analysis was made on the clinical data of 121 patients for cesarean section in who went to Maternal and Child Health Hospital of Jiaozuo City for cesarean section from January 2021 to June 2022.According to the results of EPDS,the patients were divided into the postpartum depression group(70 cases)and control group(51 cases).The levels of inflammatory factors and oxidative stress indicators in the perinatal cerebrospinal fluid and venous blood of the two groups were compared,and the predictive efficacy of the above indicators for postpartum depression after cesarean section were analyzed.Results:The levels of tumor necrosis factor⁃alpha(TNF⁃α),interleukin⁃6(IL⁃6),high⁃sensitivity C⁃reactive protein(hs⁃CRP),and malondialdehyde(MDA)in the cerebrospinal fluid and peripheral blood of the postpartum depression group were higher than those in the control group,while the levels of superoxide dismutase(SOD)and catalase(CAT)were lower than those in the control group,and the differences were statistically significant(P<0.05).Furthermore,postpartum depression is positively correlated with levels of inflammatory factors and prooxidative stress factors,while negatively correlated with levels of antioxidant stress factors,and the differences were statistically significant(P<0.05).Conclusion:Changes in inflammatory factors and oxidative stress factors during the perinatal period have a high predictive effectiveness on postpartum depression after cesarean section.