异甘草酸镁注射液在晚期宫颈癌术后辅助化疗中的应用研究

Applied research of magnesium isoglycyrrhizinate injection in postoperative adjuvant chemotherapy for advanced cervical cancer

目的:观察异甘草酸镁注射液辅助宫颈癌术后化疗的应用效果。方法:选取120例宫颈癌患者为研究对象,采用抽签法将患者分为试验组和对照组,每组各60例。对照组术后仅予以辅助化疗,试验组术后采用异甘草酸镁注射液配合化疗,比较两组治疗前、后的肝功能、炎症指标因子、氧化应激指标变化及生存情况。结果:治疗后,试验组的谷丙转氨酶/丙氨酸转氨酶(ALT)、谷草转氨酶/天冬氨酸转氨酶(AST)、纤维蛋白原(FIB)、肿瘤坏死因子⁃α(TNF⁃α)、白细胞介素⁃6(IL⁃6)、白细胞介素⁃10(IL⁃10)、皮质醇(Cor)、丙二醛(MDA)均低于对照组,而超氧化物歧化酶(SOD)、中位无进展生存期(PFS)、中位总生存期(OS)高于对照组,差异均具有统计学意义(P<0.05)。结论:晚期宫颈癌患者采用异甘草酸镁辅助化疗可减轻肝功能损伤,缓解炎症反应、氧化应激反应,并可延长生存周期。

Objective:To observe the application effects of magnesium isoglycyrrhizinate injection as an adjuvant in the postoperative chemotherapy of cervical cancer.Methods:120 patients with cervical cancer were selected as the research objects in the study.The patients were divided into the experimental group and control group by lottery drawing method,with 60 patients in each group.The control group were received only adjuvant chemotherapy after surgery,while the experimental group were received magnesium isoglycyrrhizinate injection combined with chemotherapy after surgery.The changes in liver function,inflammatory indicfactors,oxidative stress indicators,and survival status between the two groups were compared before and after treatment.Results:After treatment,glutamic⁃pyruvic transaminase/alanine aminotransferase(ALT),glutamic oxaloacetic transaminase/asparate aminotransferase(AST),fibrinogen(FIB),tumor necrosis factor⁃α(TNF⁃α),interleukin⁃6(IL⁃6),IL⁃10,cortisol(Cor),and malondialdehyde(MDA)in the experimental group were lower than those in the control group,while superoxide dismutase(SOD),median progression⁃free survival(PFS),and median overall survival(OS)were higher than those in the control group,with a statistically significant difference(P<0.05).Conclusion:The advanced cervical cancer patients can alleviate liver function damage,inflammatory reaction and oxidative stress response,and prolong the life cycle by using magnesium isoglycyrrhizinate as adjuvant chemotherapy.