加减海桐皮汤对膝骨关节炎患者膝关节功能及微炎症状况的影响

Effects of Haitongpi decoction on knee joint function and microinflammation conditions in patients with knee osteoarthritis

目的:观察加减海桐皮汤对膝骨关节炎(OA)患者膝关节功能及微炎症的作用。方法:选取96例OA患者,按照随机数字表法其分为两组,每组48例,对照组予以常规治疗,观察组予以加减海桐皮汤熏洗治疗。比较两组疗效、疼痛程度、膝关节功能及微炎症指标。结果:观察组总有效率较对照组高,差异有统计学意义(P<0.05)。治疗后,观察组视觉模拟评分(VAS)低于对照组,肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C反应蛋白(CRP)的水平均较对照组低,Lysholm膝关节评分较对照组高,以上差异均有统计学意义(P<0.05)。结论:OA患者采用加减海桐皮汤治疗,效果确切,可减轻患者疼痛程度,提高膝关节功能,改善微炎症状况。

Objective:To observe the effects of Haitongpi decoction on knee function and micro-inflammation conditions in patients with knee osteoarthritis(OA).Methods:96 cases were selected and divided into two groups by random number table method,with 48 cases in each group.The control group were given routine treatment,and the observation group were given fumigation with Haitongpi decoction.The efficacy,pain degree,knee function and microinflammation indexes were compared between the two groups.Results:The total effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).After treatment,visual analogue scale(VAS),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and C-reactive protein(CRP)levels in the treatment group were lower than those in the control group,while Lysholm knee joint scores were higher than those in the control group,with a statistical significance(P<0.05).Conclusion:The treatment effect of Haitongpi decoction in OA patients is better,which can reduce the degree of pain,improve the function of knee joint and reduce microinflammation conditions.