25-(OH)D_(3)及外周血淋巴细胞亚群水平与大叶性肺炎患儿肺功能的相关性分析

Correlation analysis of 25-(OH)D_(3) and peripheral blood lymphocyte subsets with lung function in children with lobar pneumonia

目的:分析25-(OH)D_(3)及外周血淋巴细胞亚群水平与大叶性肺炎患儿肺功能的相关性。方法:选取62例大叶性肺炎患儿为研究组,60例同期参与健康体检儿童为对照组,分别测定25-(OH)D_(3)外周血淋巴细胞亚群水平及肺功能变化。利用Pearson相关性分析25-(OH)D_(3)、外周血淋巴细胞亚群与肺功能关系。结果:研究组25-(OH)D_(3)、肺功能指标水平低于对照组,T淋巴细胞亚群水平高于对照组,差异有统计学意义(P<0.05)。Pearson分析显示,25-(OH)D_(3)、淋巴细胞亚群与肺功能水平呈线性相关,是影响小儿大叶性肺炎肺功能变化的独立影响因素(P<0.05)。ROC曲线分析显示,25-(OH)D_(3)和淋巴细胞亚群联合检查AUC值高于单项检查(P<0.05)。结论:25-(OH)D_(3)及外周血淋巴细胞亚群水平与大叶性肺炎患儿肺功能降低相关,监测两者水平变化有助于诊断小儿大叶性肺炎,并为合理制定治疗方案提供参考。

Objective:To analyze the correlation between 25-(OH)D_(3) and peripheral blood lymphocyte subsets and lung function in children with lobar pneumonia.Methods:62 children with lobar pneumonia diagnosed were selected as the study group,and 60 healthy children who participated in physical examination during the same period were selected as the control group.25-(OH)D_(3) peripheral blood lymphocyte subsets and lung function changes were determined,respectively.The relationship between 25-(OH)D_(3),peripheral blood lymphocyte subsets and lung function was analyzed.Results:The levels of 25-(OH)D_(3) and lung function indicators in the study group were lower than those in the control group,while the levels of T lymphocyte subsets were higher than those in the control group,and the difference was statistically significant(P<0.05).Pearson analysis showed that 25-(OH)D_(3) and lymphocyte subsets were linearly correlated with lung function,and were independent factors affecting lung function in children with lobar pneumonia(P<0.05).ROC curve analysis showed that the AUC value of the combined examination of 25-(OH)D_(3) and lymphocyte subpopulations was higher than that of the single examination(P<0.05).Conclusion:The levels of 25-(OH)D_(3) and peripheral blood lymphocyte subsets are associated with decreased lung function in children with lobar pneumonia.Monitoring the changes of both levels is helpful for the diagnosis of lobar pneumonia in children and for the rational formulation of treatment plan.