新斯的明在老年腹腔镜手术麻醉中的应用效果

Application effects of neostigmine in elderly laparoscopic surgery anesthesia

目的:观察新斯的明在老年腹腔镜手术麻醉中的应用效果。方法:选取121例行腹腔镜手术老年患者,结合患者治疗指征分为对照组50例和观察组71例。对照组采用常规全身麻醉辅助手术治疗,观察组采用新斯的明配合全麻辅助手术治疗,比较两组术前、术后认知功能评分,大脑神经功能指标变化情况,术后认知障碍发生情况,及药物相关不良反应发生情况。结果:术后,观察组MMSE、MoCA评分均高于对照组,NSE、S-100β均低于对照组,差异有统计学意义(P<0.05)。术后,观察组的认知障碍发生率低于对照组(P<0.05)。药物相关不良反应发生率略高于对照组(P>0.05)。结论:新斯的明能有效改善老年腹腔镜手术患者的大脑神经功能和认知功能,并降低肌松残余所致认知障碍发生率,安全性较高,未明显增加药物不良反应的发生风险。

Objective:To observe the application effect of neostigmine in elderly laparoscopic surgery anesthesia.Methods:121 elderly patients undergoing laparoscopic surgery were selected and divided into the control group(50 cases)and observation group(71 cases)based on their treatment indications.The control group were treated with conventional general anesthesia assisted surgery,while the observation group were treated with neostigmine combined with general anesthesia assisted surgery.The preoperative and postoperative cognitive function scores,changes in brain nerve function indicators,and postoperative cognitive impairment,and the occurrence of drug-related adverse reactions were compared between the two groups.Results:After surgery,the MMSE and MoCA scores of the observation group were higher than those of the control group,while NSE and S-100βwere lower than those in the control group and the differences were statistically significant(P<0.05).After surgery,the incidence of cognitive impairment in the observation group was lower than that in the control group(P<0.05).The incidence of drug-related adverse reactions was slightly higher than that of the control group(P>0.05).Conclusion:Neostigmine can effectively improve the cerebral nervous function indicators of elderly patients undergoing laparoscopic surgery,improve cognitive function,and reduce the incidence of cognitive impairment caused by residual muscle relaxation.It has high safety and does not significantly increase the risk of adverse drug reactions.