高通量透析联合硫代硫酸钠治疗尿毒症的效果

Effects of high-flux dialysis combined with sodium thiosulfate on improving the treatment of uremia

目的:探究高通量透析联合硫代硫酸钠治疗尿毒症的效果。方法:选取2021年8月至2023年1月收治的尿毒症患者68例作为研究对象,按照随机原则分为对照组与观察组,每组34例。对照组采用高通量血液透析治疗,观察组采用高通量透析联合硫代硫酸钠治疗。治疗后,比较两组的血清Ca^(2+)、肌酐(Scr)、尿素氮(BUN)和甲状旁腺激素水平,分析两组的机体功能、生活状况以及不良反应。结果:治疗3个月后,观察组的生活状况UP-Dial评分、PSQI评分低于对照组,SF-36评分高于对照组,差异有统计学意义(P<0.05)。观察组的机体功能指标动脉血氧分压(PaO_(2))、经皮血氧饱和度(SpO_(2))高于对照组(P<0.05)。观察组血清Ca^(2+)、Scr、BUN和PTH水平低于对照组。结论:高通量透析联合硫代硫酸钠治疗尿毒症,可有效缓解皮肤瘙痒症状,改善机体功能,提升患者生活质量。

Objective:To explore the effects of high-flux dialysis combined with sodium thiosulfate on improving the treatment of uremia.Methods:68 patients with uremia admitted from August 2021 to January 2023 were selected as the study subjects and were divided into the control group and observation group according to dynamic randomization method,with 34 cases in each group.The patients in the control group were treated with ordinary dialysis,while the patients in the observation group were received high-flux hemodialysis combined with sodium thiosulfate.After treatment,the levels of serum Ca^(2+),creatinine(Scr),urea nitrogen(BUN),and parathyroid hormone were compared between the two groups,and the body function,living conditions,and adverse reactions were analysed between the two groups of patients.Results:After 3 months of treatment,the uremic pruritus in dialysis patients scale(UP-Dial)score and Pittsburgh sleep quality index(PSQI)score of the observation group were lower than those of the control group,while the short form 36 health survey(SF-36)score was higher than that of the control group,with a statistically significant difference(P<0.05).The body functional indicators of the observation group were higher than those of the control group(P<0.05),including arterial oxygen partial pressure(PaO_(2))and percutaneous oxygen saturation(SpO_(2)).The serum levels of Ca^(2+),Scr,BUN,and PTH in the observation group were lower than those in the control group.Conclusion:High-flux dialysis combined with sodium thiosulfate can effectively relieve the itching symptoms,enhance the quality of life,and regulate the body function and parathyroid hormones levels in patients with uremia.