银杏内酯联合阿替普酶溶栓治疗急性脑梗死的效果

Effect of Ginkgolide Combined with Alteplase Thrombolysis in the Treatment of Acute Cerebral Infarction

目的:观察银杏内酯联合阿替普酶溶栓治疗急性脑梗死的效果。方法:选取2019年1月—2022年8月大田县总医院收治的110例急性脑梗死患者。根据随机数表法将其分为研究组55例和对照组55例。两组均给予一般治疗,对照组给予注射用阿替普酶溶栓治疗,研究组在对照组的基础上给予银杏内酯注射液。比较两组治疗前后日常活动能力、肢体运动功能、神经功能缺损、病情、血小板指标,并发症及临床疗效。结果:治疗后,两组Barthel指数(BI)评分、Fugl-Meyer肢体运动功能量表(FMA)评分均高于治疗前,研究组BI评分、FMA评分均高于对照组,差异有统计学意义(P<0.05)。治疗后,两组美国国立卫生院卒中量表(NIHSS)评分、改良Rankin量表(mRS)评分均低于治疗前,研究组NIHSS评分、m RS评分均低于对照组,差异有统计学意义(P<0.05)。治疗后,两组血小板聚集率、血小板黏附率均低于治疗前,研究组血小板聚集率、血小板黏附率均低于对照组,差异有统计学意义(P<0.05)。研究组并发症发生率低于对照组,差异有统计学意义(P<0.05)。研究组总有效率高于对照组,差异有统计学意义(P<0.05)。结论:银杏内酯联合阿替普酶溶栓在急性脑梗死患者治疗中效果较好,能够显著促进神经系统与肢体功能的恢复,改善血小板聚合状态。

Objective:To observe the effect of Ginkgolide combined with Alteplase thrombolysis in the treatment of acute cerebral infarction.Method:A total of 110 patients with acute cerebral infarction treated in Datian General Hospital from January 2019 to August 2022 were selected.According to the random number table method,they were divided into study group of 55 cases and control group of 55 cases.Both groups were given general treatment,the control group was given thrombolytic therapy with Alteplase for Injection,and the study group was given Ginkgolide Injection on the basis of the control group.The daily activity ability,limb motor function,neural function deficit,disease condition,platelet index before and after treatment,complications and clinical effect were compared between the two groups.Result:After treatment,Barthel index(BI)and Fugl-Meyer limb motor function scale(FMA)scores of both groups were higher than those before treatment,and BI and FMA scores of the study group were higher than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the National Institutes of Health stroke scale(NIHSS)and modified Rankin scale(mRS)scores in both groups were lower than those before treatment,and the NIHSS and mRS scores in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the platelet aggregation rate and platelet adhesion rate of the two groups were lower than those before treatment,and the platelet aggregation rate and platelet adhesion rate of the study group were lower than those of the control group,and the differences were statistically significant(P<0.05).The incidence of complication of the study group was lower than that of the control group,and the difference was statistically significant(P<0.05).The total effective rate of the study group was higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion:The effect of Ginkgolide combined with Alteplase thrombolysis in the treatment of patients with acute cerebral infarction is good,which can significantly promote the recovery of nervous system and limb function,improve the platelet aggregation state.