脑干听觉诱发电位在孤独症谱系障碍患儿中的特征分析

Analyze the Characteristic of Brainstem Auditory Evoked Potential in Children with Autism Spectrum Disorders

目的:分析脑干听觉诱发电位(BAEP)在孤独症谱系障碍(ASD)患儿中的特征。方法:选取2020年1月—2023年1月厦门市仙岳医院收治的100例ASD患儿为观察组,另取同期体检健康儿童26例为对照组,对其BAEP检测结果进行统计。对观察组实施听觉统合训练,观察干预效果。结果:两组Ⅰ波与Ⅲ波潜伏期比较,差异无统计学意义(P>0.05),观察组Ⅴ波潜伏期长于对照组,差异有统计学意义(P<0.05)。两组Ⅰ波、Ⅲ波波间差比较,差异无统计学意义(P>0.05),观察组Ⅲ波、Ⅴ波,Ⅰ波、Ⅴ波波间差均大于对照组,差异有统计学意义(P<0.05)。治疗后2周、1个月,异常组孤独症治疗评定量表(ATEC)评分均低于非异常组,差异有统计学意义(P<0.05)。治疗前和治疗后2周,异常组儿童孤独症评定量表(CARS)评分均低于非异常组,差异有统计学意义(P<0.05);异常组治疗前和治疗后2周CARS评分差值均大于非异常组,差异有统计学意义(P<0.05)。结论:BAEP检测能够为ASD患儿诊断提供依据,且听觉统合训练对于BAEP异常患儿症状改善更为显著。

Objective:To analyze the characteristics of brainstem auditory evoked potential(BAEP)in children with autism spectrum disorder(ASD).Method:A total of 100 children with ASD admitted to Xiamen Xianyue Hospital from January 2020 to January 2023 were selected as the observation group,and 26 healthy children in the same period were selected as the control group.The results of BAEP detection were statistically analyzed.Auditory integration training was carried out in the observation group,the effect of intervention were observed.Result:There were no significant differences between the latency ofⅠwave andⅢwave between the two groups(P>0.05),but the latency ofⅤwave in the observation group was longer than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the interwave difference value betweenⅠwave andⅢwave between the two groups(P>0.05),but the interwave difference value betweenⅢwave andⅤwave,Ⅰwave andⅤwave in the observation group were greater than those in the control group,the differences were statistically significant(P<0.05).At 2 weeks and 1 month after treatment,the autism treatment evaluation checklist(ATEC)score of the abnormal group were lower than those of the non-abnormal group,and the differences were statistically significant(P<0.05).Before treatment and 2 weeks after treatment,the scores of childhood autism rating scale(CARS)in abnormal group were lower than those in non-abnormal group,and the differences were statistically significant(P<0.05).The difference value of CARS scores before treatment and 2 weeks after treatment in abnormal group was greater than that in non-abnormal group,and the difference was statistically significant(P<0.05).Conclusion:BAEP detection can provide a basis for the diagnosis of ASD children,and the symptoms of children with abnormal BAEP are more significantly improved during auditory integration training.