儿童难治性哮喘的影响因素及机制研究

Study on the effects and mechanism of on refractory asthma in children

儿童难治性哮喘严重影响儿童肺功能及生活质量。国内尚无儿童难治性哮喘诊疗指南。该文从基因、环境、社会心理因素等方面对儿童难治性哮喘研究进展进行了综述。通过基因检测及生物学指标对儿童难治性哮喘进行早期识别及基于分子水平的个体化治疗,并结合控制环境因素和社会心理因素调节对儿童难治性哮喘防控提供新的思路。

Refractory asthma in children seriously affects their lung function and quality of life.There are no guidelines for the diagnosis and treatment of refractory asthma in children in China.This article reviews the research progress on childhood refractory asthma in terms of genetic,environmental,socio-psychological factors.Through genetic testing and biological indicators,early identification of refractory asthma in children and individualized treatment based on molecular level,combined with the control of environmental factors and psychosocial factors,provide new ideas for the prevention and control of refractory asthma in children.