连续性肾脏替代治疗的净超滤率与预后

Net ultrafiltration rate and prognosis of continuous renal replacement therapy

连续性肾脏替代治疗(CRRT)的净超滤率(UF^(net )rate),即患者接受CRRT期间根据患者体重调整的净液体清除速度,已被广泛应用于急性肾损伤(AKI)及容量过负荷(FO)患者的液体管理。目前临床指南并未明确指出UF^(net)与患者死亡率等预后指标之间的关系。而且,由于危重症患者原发病不同且疾病严重程度差异大,目前关于UF^(net)的研究结论存在争议。因此本文将CRRT的UF^(net)对危重症患者预后的预测价值作一述评,旨在为临床提供一定的参考。

The net ultrafiltration rate(UF^(net) rate),defined as the rate of net fluid clearance adjusted for the patient′s weight,has been used in continuous renal replacement therapy(CRRT)of patients with acute kidney injury(AKI)and fluid overload(FO)for several years.Current clinical guidelines do not clearly indicate the relationship between UF net and prognostic indicators such as patient mortality.Moreover,the findings on UF net are controversial due to the different primary morbidities and the wide range of disease severity in critically ill patients.Therefore,in this article,the predictive value of UF net of CRRT on the prognosis of critically ill patients is reviewed.