来曲唑联合地塞米松对多囊卵巢综合征患者血清Galectin-3及HSP70的影响

Effects of Letrozole combined with dexamethasone on serum Galectin-3 and HSP70 in patients with polycystic ovary syndrome

目的 探讨来曲唑联合地塞米松对多囊卵巢综合征(PCOS)患者血清半乳糖凝集素-3(Galectin-3)及热休克蛋白(HSP70)表达的影响。方法 选择2019年6月—2021年6月在我院治疗的PCOS患者220例为研究对象,按随机数表法分为对照组(n=110)和观察组(n=110),对照组常规给予来曲唑治疗。观察组在对照组的基础上加用地塞米松联合治疗。观察并比较两组患者的激素水平,促排卵情况,血清抗苗勒管激素(AMH)、Galectin-3、HSP70及单核细胞趋化蛋白-1(MCP-1)水平及不良反应发生率。结果 治疗后两组患者的性激素水平均改善,且观察组变化幅度高于对照组(P<0.05)。观察组患者雌二醇(E_(2))用量低于对照组,成熟卵泡数量和最大卵泡直径均高于对照组(均P<0.05)。两组患者的早期流产率差异无统计学意义(P>0.05);观察组患者的妊娠率高于对照组(P<0.05)。治疗前两组患者AMH、Galectin-3、HSP70、MCP-1水平差异无统计学意义(P>0.05),治疗后两组患者的AMH、Galectin-3、HSP70、MCP-1水平均降低,且观察组低于对照组(P<0.05)。观察组和对照组分别有35例和34例出现胃肠道反应、头痛、乳房胀痛等不良反应,两组差异无统计学意义(χ^(2)=0.021,P=0.885)。结论 来曲唑联合地塞米松可能减轻氧化应激反应,减轻胰岛素抵抗,调节激素水平,促进排卵,安全性高,值得推广应用。

Objective To study effects of letrozole combined with dexamethasone on serum Galectin-3 as well as HSP70 in patients with polycystic ovary syndrome(PCOS).Methods Two hundred and twenty patients with PCOS treated in our hospital from June 2019 to June 2021 were selected for the study and divided into two groups according to the random number table method,and 110 cases in the control group were routinely given letrozole treatment.In the observation group,dexamethasone was added to the control group as a combination treatment.The hormone levels,ovulation promotion,serum Anti Miillerian Hormone(AMH),Galectin-3(Galectin-3),Heat shock protein 70(HSP70)and monocyte chemotactic protein-1(Monocyte chemotactic protein-1)were observed and compared between the two groups.The levels of monocyte chemotactic protein-1(MCP-1)and the incidence of adverse reactions were investigated.Results After treatment,the levels of sex hormones in the two groups were changed better,and the change in the observation group was higher than that in the control group(P<0.05).The amount of estradiol in the observation group was lower than that in the control group(P<0.05),and the number of mature follicles and maximum follicle diameter were higher than those in the control group(P<0.05).There was no significant difference in the early miscarriage rate between the two groups(P>0.05);the pregnancy rate in the observation group was higher than that in the control group(P<0.05).There was no significant difference in AMH,Galectin-3,HSP70,and MCP-1 levels between the two groups before treatment(P>0.05);AMH,Galectin-3,HSP70,and MCP-1 levels decreased in both groups after treatment,and the observation group was lower than the control group(P<0.05).There were 35 and 34 cases of adverse reactions such as gastrointestinal reactions,headache and breast distension in the observation group and control group,respectively,and the difference between the two groups was not statistically significant(χ^(2)=0.021,P=0.885).Conclusion Letrozole combined with dexamethasone may reduce oxidative stress,alleviate insulin resistance,regulate hormone levels,and promote ovulation with high safety,which is worth promoting the application.