西医常规治疗联合芪蛭通络胶囊对急性缺血性脑卒中介入术后患者恢复的临床研究

Clinical Study on Patients’Recovery After Acute Ischemic Stroke Intervention by Conventional Western Medicine Combined with Qizhi Tongluo Capsules

目的:探讨西医常规治疗联合芪蛭通络胶囊对急性缺血性脑卒中介入术后患者恢复的临床效果。方法:选取2019年6月至2021年12月就诊于该院介入科的急性缺血性脑卒中患者86例,介入术后按照随机数字表法分组,其中对照组患者43例,给予阿司匹林及常规康复治疗;观察组患者43例,在对照组的基础上联合芪蛭通络胶囊治疗。连续治疗3个月后,比较两组患者的临床疗效、神经功能损伤程度[美国国立卫生院卒中神经功能缺损评分量表(NIHSS)评分]、血液流变学指标(全血高切黏度、全血低切黏度和血浆黏度)水平、生活质量评分[日常生活活动(ADL)评分]及不良反应发生情况。结果:治疗3个月后,观察组患者的总有效率为93.0%(40/43),高于对照组的76.7%(33/43),差异有统计学意义(P<0.05)。两组患者治疗后的NIHSS评分均较治疗前降低,且观察组患者低于对照组,差异均有统计学意义(P<0.05)。两组患者治疗后全血高切黏度、全血低切黏度和血浆黏度均较治疗前降低,且观察组患者低于对照组,差异均有统计学意义(P<0.05)。两组患者治疗后ADL评分均较治疗前升高,观察组患者高于对照组,差异均有统计学意义(P<0.05)。观察组患者的不良反应发生率为7.0%(3/43),低于对照组的18.6%(8/43),但差异无统计学意义(P>0.05)。结论:西医常规治疗联合芪蛭通络胶囊治疗急性缺血性脑卒中介入术后患者的疗效明确,可改善患者神经功能损伤程度,调节血液流变学,提高患者生活质量,且安全性高。

OBJECTIVE:To probe into the clinical effect of conventional Western medicine combined with Qizhi Tongluo capsules on patients'recovery after acute ischemic stroke intervention.METHODS:A total of 86 patients with acute ischemic stroke underwent interventional operation in the interventional medicine department of Xuzhou Cancer Hospital from Jun.2019 to Dec.2021 were selected and divided via the random number table method,43 cases in the control group were given aspirin and conventional rehabilitation treatment;43 cases in the observation group received Qizhi Tongluo capsules on the basis of the control group.After continuous treatment for 3 months,the clinical efficacy,degree of neurological impairment[National Institutes of Health Stroke Neurologic Deficit Scale(NIHSS)scores],hemorheological indicators(whole blood high shear viscosity,whole blood low shear viscosity and plasma viscosity level),quality of life score[activities of daily living(ADL)scores]and incidences of adverse drug reactions were compared between two groups.RESULTS:After 3 months of treatment,the total effective rate of the observation group was 93.0%(40/43),which was higher than that of the control group(76.7%,33/43),with statistically significant difference(P<0.05).The NIHSS scores of both groups decreased significantly after treatment compared with those before treatment,and the NIHSS scores in the observation group was lower than that in the control group,with statistically significant differences(P<0.05).The whole blood high shear viscosity,whole blood low shear viscosity and plasma viscosity levels of both groups decreased compared with those before treatment,and the above indicators in the observation group were lower than those in the control group,with statistically significant differences(P<0.05);the ADL scores of both groups increased compared with those before treatment,and the ADL scores in the observation group was higher than that in the control group,with statistically significant differences(P<0.05).The incidences of adverse drug reactions of the observation group was 7.0%(3/43),lower than that of the control group(18.6%,8/43),the difference was not statistically significant(P>0.05).CONCLUSIONS:The efficacy of conventional Western medicine combined with Qizhi Tongluo capsules in the treatment of patients with acute ischemic stroke after interventional surgery is remarkable,which can improve neurological function damage,regulate hemorheology,promote the quality of life,with high safety.