蔡氏内异Ⅲ方治疗湿热瘀结型子宫内膜异位症的临床疗效研究

Clinical Efficacy of Cai’s Endometriosis Ⅲ Formula in the Treatment of Endometriosis Syndrome of Damp-Heat and Blood Stasis

目的:探讨蔡氏内异Ⅲ方用于湿热瘀结型子宫内膜异位症(EMS)患者的疗效。方法:选取2021年7月至2022年12月上海中医药大学附属曙光医院收治的湿热瘀结型EMS患者40例,采用蔡氏内异Ⅲ方治疗2个疗程(6个月经周期)。2个疗程结束后,比较患者治疗前后视觉模拟评分(VAS)、中医证候评分、盆腔包块体积和血清糖类抗原125(CA125)水平。结果:治疗前,患者的VAS评分为(6.16±1.44)分,中医证候评分为(23.78±7.80)分;治疗后,患者的VAS评分为(5.18±1.58)分,中医证候评分为(20.15±5.94)分,均较治疗前降低,差异均有统计学意义(P<0.05)。患者治疗后的血清CA125水平较治疗前降低,B超囊肿较治疗前减小,差异均有统计学意义(Z=-2.401、-2.514,P<0.05)。结论:蔡氏内异Ⅲ方能降低患者VAS评分,从而减轻患者疼痛症状,改善中医证候,降低血清CA125水平,抑制卵巢子宫内膜异位囊肿增长速度。

OBJECTIVE:To probe into the efficacy of Cai's endometriosis Ⅲ formula in the treatment of endometriosis syndrome of damp-heat and blood stasis.METHODS:Forty patients with endometriosis syndrome of damp-heat and blood stasis admitted into Shuguang Hospital of Shanghai University of Traditional Chinese Medicine from Jul.2021 to Dec.2022 were extracted and treated with Cai's endometriosis Ⅲ formula for 2 courses of treatment(6 menstrual cycles).Visual analogue scale(VAS),traditional Chinese medicine syndrome score,pelvic mass volume and serum CA125 level were compared before and after 2 courses of treatment.RESULTS:Before treatment,the VAS score of the patient was(6.16±1.44) points and traditional Chinese medicine syndrome score was(23.78±7.80) points.After treatment,the VAS score of the patients was(5.18±1.58) points,and traditional Chinese medicine syndrome score was(20.15±5.94) points,both of which decreased compared to before treatment,with statistically significant differences(P<0.05).After treatment,the CA125 level of the patients was lower than that before treatment,and the cysts of B-ultrasound were lower than that before treatment,with statistically significant difference(Z=-2.401,-2.514,P<0.05).CONCLUSIONS:Cai's endometriosis Ⅲ formula can reduce patients' VAS score,alleviate pain symptoms,improve traditional Chinese medicine symptom,decrease blood CA125,and inhibit the growth of ovarian endometriosis cysts.