长效胰岛素联合口服降糖药治疗2型糖尿病的疗效

Effect of long-acting insulin combined with oral hypoglycemic drugs on type 2 diabetes mellitus

目的 分析2型糖尿病(T2DM)采取长效胰岛素+口服降糖药治疗的效果。方法 96例T2DM患者,随机分为观察组和对照组,每组48例。对照组给予口服降糖药治疗,观察组给予长效胰岛素+口服降糖药治疗。比较两组患者治疗前后的血糖[糖化血红蛋白(HbA1c)、餐后2 h血糖(2 h PG)、空腹血糖(FPG)]水平、生活质量(总体健康、精力、社会功能、心理健康、躯体疼痛、躯体角色功能、情绪角色功能、躯体健康)评分以及不良反应发生情况(体重增加、低血糖)、治疗效果。结果 治疗后,观察组患者HbA1c(6.20±0.91)%、2 h PG(8.63±1.37)mmol/L、FPG(5.83±0.72)mmol/L均低于对照组的(8.34±1.15)%、(9.56±1.60)mmol/L、(7.91±1.31)mmol/L,差异具有统计学意义(P<0.05)。观察组不良反应发生率2.08%(1/48)低于对照组的14.58%(7/48),差异具有统计学意义(χ^(2)=4.909,P<0.05)。治疗后,观察组患者总体健康评分(63.25±4.48)分、精力评分(74.25±4.54)分、社会功能评分(83.67±3.91)分、心理健康评分(81.48±4.25)分、躯体疼痛评分(74.48±6.38)分、躯体角色功能评分(73.54±4.18)分、情绪角色功能评分(84.54±3.67)分、躯体健康评分(71.37±4.28)分;对照组患者总体健康评分(54.54±3.25)分、精力评分(61.22±4.01)分、社会功能评分(76.32±2.75)分、心理健康评分(61.24±3.75)分、躯体疼痛评分(66.58±4.70)分、躯体角色功能评分(61.24±4.42)分、情绪角色功能评分(73.05±2.50)分、躯体健康评分(52.31±2.76)分。观察组患者总体健康、精力、社会功能、心理健康、躯体疼痛、躯体角色功能、情绪角色功能、躯体健康评分均高于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率95.83%高于对照组的79.17%,差异具有统计学意义(P<0.05)。结论 长效胰岛素联合口服降糖药物对T2DM治疗可有效改善血糖水平,降低不良反应发生率,提升疗效。

Objective To analyze the effect of long-acting insulin+oral hypoglycemic drugs on type2 diabetes mellitus (T2DM).Methods 96 patients with T2DM were randomly divided into the observation group and the control group,with 48 cases in each group.The control group was treated with oral hypoglycemic drugs,and the observation group was treated with long-term insulin+oral hypoglycemic drugs.Comparison was made on blood glucose[glycosylated hemoglobin (HbA1c),2-h postprandial glucose (2 h PG),fasting plasma glucose (FPG)]level,quality of life (general health,energy,social functioning,mental health,physical pain,somatic role functioning,emotional role functioning,physical health) score before and after treatment,occurrence of adverse reactions (weight gain,hypoglycemia),and treatment effect between the two groups.Results After treatment,the observation group had HbA1c of (6.20±0.91)%,2 h PG of (8.63±1.37) mmol/L and FPG of(5.83±0.72) mmol/L,which were lower than those of (8.34±1.15)%,(9.56±1.60) mmol/L and (7.91±1.31) mmol/L in the control group,and the difference was statistically significant (P<0.05).The incidence of adverse reactions in the observation group was 2.08%(1/48),which was lower than 14.58%(7/48) in the control group,and the difference was statistically significant (χ^(2)=4.909,P<0.05).After treatment,the general health score of the observation group was (63.25±4.48) points,the energy score was (74.25±4.54) points,the social functioning score was (83.67±3.91) points,the mental health score was (81.48±4.25) points,the physical pain score was (74.48±6.38) points,the somatic role functioning score was (73.54±4.18) points,the emotional role functioning score was (84.54±3.67) points,and the physical health score was (71.37±4.28) points.The general health score of the control group was (54.54±3.25) points,the energy score was (61.22±4.01) points,the social functioning score (76.32±2.75) points,the mental health score was (61.24±3.75) points,the physical pain score was (66.58±4.70) points,the somatic role functioning score was (61.24±4.42) points,the emotional role functioning score (73.05±2.50) points,and the physical health score was (52.31±2.76) points.The scores of general health,energy,social functioning,mental health,physical pain,somatic role functioning,emotional role functioning,physical health in the observation group were higher than those in the control group,and the difference was statistically significant (P<0.05).The total effective rate of 95.83%in the observation group was higher than that of 79.17%in the control group,and the difference was statistically significant (P<0.05).Conclusion The combination of long-acting insulin and oral hypoglycemic drugs for can effectively improve the blood glucose level,reduce incidence of adverse reactions and improve the efficacy of T2DM.