除湿胃苓汤联合糠酸莫米松乳膏对湿疹患者的疗效研究

Study on the Therapeutic Effect of Qushi Weiling Decoction Combined with Mometasone Furoate Cream on Patients with Eczema

目的研究除湿胃苓汤联合糠酸莫米松乳膏对湿疹患者的疗效。方法选择2020年5月—2022年5月渭南市第二医院收治的82例湿疹患者作为研究对象,依据随机数表法分为两组,分别为对照组和观察组。对照组采用糠酸莫米松乳膏治疗,观察组在对照组治疗基础上联用除湿胃苓汤。评估两组的症状评分和生活质量,且检测血清白细胞介素-2(IL-2)、芳香烃受体(AhR)、γ干扰素(IFN-γ)和白细胞介素-4(IL-4)水平。结果治疗后,两组的皮损形态、瘙痒程度、皮肤渗液程度和皮损面积评分均明显降低(P<0.05),且观察组的皮损形态、瘙痒程度、皮肤渗液程度和皮损面积评分更低,差异有统计学意义(P<0.05);治疗后,两组的血清AhR和IL-4水平均明显降低(P<0.05),IL-2、IFN-γ水平明显升高(P<0.05),且观察组的血清AhR和IL-4水平明显低于对照组,差异有统计学意义(P<0.05),IL-2、IFN-γ水平明显高于对照组,差异有统计学意义(P<0.05);治疗后,两组的经济负担、穿戴、运动、心理、工作学习、生理、性生活、日常生活、社交娱乐及家庭关系评分均明显降低(P<0.05),且观察组的经济负担、穿戴、运动、心理、工作学习、生理、性生活、日常生活、社交娱乐及家庭关系评分更低,差异有统计学意义(P<0.05)。结论除湿胃苓汤联合糠酸莫米松乳膏对湿疹患者有显著的疗效,能明显减轻症状,改善细胞因子水平,提高生活质量。

Objective To study the therapeutic effect of Qushi Weiling decoction combined with mometasone furoate cream on patients with eczema.Methods Selected 82 cases of patients with eczema who were treated in our hospital from May 2020 to May 2022,divided into two groups randomly.The control group was treated with mometasone furoate cream,while the observation group was treated with dehumidifying Weiling decoction.Evaluate the symptom scores and quality of life of both groups,and detect serum interleukin-2(IL-2),aromatic hydrocarbon receptor(AhR)γ Interferon(IFN-γ)And interleukin-4(IL-4)levels.Results After treatment,the skin lesion morphology,itching degree,skin exudation degree,and skin lesion area score of the two groups were significantly reduced(P<0.05),and the observation group had lower skin lesion morphology,itching degree,skin exudation degree,and skin lesion area score(P<0.05).After treatment,the serum levels of AhR and IL-4 in both groups were significantly reduced(P<0.05),IL-2,IFN-γ The level significantly increased(P<0.05),and the serum AhR and IL-4 levels in the observation group were significantly lower(P<0.05),IL-2,IFN-γ level was significantly higher(P<0.05).After treatment,the scores of economic burden,clothing,exercise,psychology,work learning,physiology,sexual life,daily life,social entertainment,and family relations in both groups were significantly reduced(P<0.05),and the scores of economic burden,clothing,exercise,psychology,work learning,physiology,sexual life,daily life,social entertainment,and family relations in the observation group were lower(P<0.05).Conclusion The combination of Qushi Weiling Tang and mometasone furoate cream has a significant therapeutic effect on patients with eczema,which can significantly alleviate symptoms,improve cytokine levels,and improve quality of life.