HPV感染相关CIN患者血清HLA-E和HLA-G表达与疾病进展及治疗后复发的相关性

Association of serum HLA-E and HLA-G expression with disease progression and post-treatment recurrence in patients with HPV infection-associated CIN

目的探讨人乳头瘤病毒(HPV)感染相关宫颈上皮内瘤变(CIN)患者血清人类白细胞抗原E(HLA-E)、人类白细胞抗原G(HLA-G)表达及临床意义。方法选取2021年6~12月在河北中石油中心医院治疗的HPV感染相关CIN患者120例作为观察组,选取同期无HPV感染的CIN患者60例作为对照组,检测两组血清HLA-E和HLA-G表达水平,分析血清HLA-E和HLA-G表达与患者临床资料、治疗后复发的关系。结果观察组血清HLA-E和HLA-G水平分别为(75.59±18.28)pg/mL和(30.20±9.92)ng/mL,高于对照组,差异有统计学意义(P<0.05)。观察组CIN分级Ⅱ/Ⅲ级患者血清HLA-E和HLA-G分别为(83.33±13.90)pg/mL和(34.54±7.18)ng/mL,高于CIN分级Ⅰ级(P<0.05);观察组高危型HPV感染者血清HLA-E和HLA-G分别为(78.82±17.70)pg/mL和(32.23±9.43)ng/mL,高于低危型HPV感染者(P<0.05)。观察组血清HLA-E和HLA-G表达与CIN分级呈正相关(P<0.05)。复发患者治疗后1周血清HLA-E和HLA-G分别为(68.32±8.73)pg/mL和(24.43±5.58)ng/mL,高于未复发患者(P<0.05)。结论HPV感染相关CIN患者血清HLA-E和HLA-G表达与CIN分级呈正相关,同时与患者治疗后复发有一定关系。

Objective To investigate the expression and clinical significance of human leukocyte antigen E(HLA-E)and human leukocyte antigen G(HLA-G)in serum of patients with cervical intraepithelial neoplasia(CIN)associated with human papillomavirus(HPV)infection.Methods A total of 120 cases of CIN patients with HPV infection treated in Hebei China Petroleum Central Hospital from June 2021 to December 2021 were selected as the observation group,and 60 cases of CIN patients without HPV infection in the same period were selected as the control group,the expressions of HLA-E and HLA-G in serum of the two groups were detected,and the relationship between the expressions of HLA-E and HLA-G in serum and the clinical data of patients and postoperative recurrence was analyzed.Results The level of serum HLA-E and HLA-G in the observation group was(75.59±18.28)pg/mL and(30.20±9.92)ng/mL,respectively,which was significantly higher than that in the control group(P<0.05).The level of serum HLA-E and HLA-G in patients with CIN grade II/Ⅲwas(83.33±13.90)pg/mL and(34.54±7.18)ng/mL,respectively,which was significantly higher than that in patients with CIN gradeⅠ(P<0.05).The serum HLA-E and HLA-G level in patients with high-risk HPV infection in the observation group was(78.82±17.70)pg/mL and(32.23±9.43)ng/mL,respectively,which was significantly higher than that in patients with low-risk HPV infection(P<0.05).The expression of HLA-E and HLA-G in serum of the observation group was positively correlated with CIN grade(P<0.05).Serum HLA-E and HLA-G in patients with recurrence one week after operationwas(68.32±8.73)pg/mL and(24.43±5.58)ng/mL,respectively,which was significantly higher than that in patients without recurrence(P<0.05).Conclusion Serum HLA-E and HLA-G expressions in patients with CIN associated with HPV infection are positively correlated with CIN grade,along with postoperative recurrence.