参麦注射液治疗气阴两虚型胃癌癌因性疲乏的临床研究

Clinical Efficacy Observation of Shenmai Injection in the Treatment of Cancer-related Fatigue in Gastric Cancer with Qi and Yin Deficiency Type

目的:探讨参麦注射液干预治疗气阴两虚型胃癌癌因性疲乏的临床疗效。方法:选取2020年9月至2022年10月靖江市中医院脾胃病、肿瘤病科收治的气阴两虚型胃癌癌因性疲乏患者66例作为研究对象,按照随机、平行对照的原则将其划分为对照组与观察组,每组33例。在研究过程中脱落6例,最后60例进入统计学分析,每组30例。对照组患者使用常规对症治疗,观察组患者在常规对症治疗的基础上加用参麦注射液,两组患者均治疗14 d。比较两组患者治疗前后效果、Piper疲乏量表(PFS)评分、卡氏(KPS)评分、中医证候积分及不良反应情况。结果:治疗后观察组患者PFS评分、中医证候积分低于对照组,KPS评分高于对照组,差异具有统计学意义(P<0.05);观察组患者治疗总有效率为73.33%,高于对照组的46.67%,差异具有统计学意义(P<0.05);两组患者治疗期间均未出现药物不良反应。结论:参麦注射液治疗气阴两虚型胃癌癌因性疲乏有较好疗效,且具有较好安全性。

Objective To explore the clinical efficacy of Shenmai Injection intervention in the treatment of cancer-related fatigue in gastric cancer with Qi and Yin deficiency type.Methods Sixty six patients with Qi and Yin deficiency type gastric cancer induced fatigue admitted to the Department of Spleen and Stomach Diseases and Oncology at Jingjiang Traditional Chinese Medicine Hospital from September 2020 to October 2022 were selected as the study subjects.They were randomly and parallelly divided into a control group and an observation group,with 33 cases in each group.During the research process,6 cases were dropped,and the last 60 cases entered statistical analysis,with 30 cases in each group.The control group patients received routine symptomatic treatment,while the observation group patients received an additional injection of Shenmai Injection on the basis of routine symptomatic treatment.Both groups of patients were treated for 14 days.The effects before and after treatment,Piper fatigue scale(PFS)score,Karnofsky performance status(KPS)score,traditional Chinese medicine syndrome score and adverse reactions were compared between the two groups.Results After treatment,the PFS score and traditional Chinese medicine syndrome score of the observation group were lower than those of the control group,and the KPS score was higher than that of the control group,with statistical significance(P<0.05);The total effective rate of the observation group was 73.33%,which was higher than 46.67%of the control group's,and the difference was statistically significant(P<0.05);Both groups of patients did not experience any adverse drug reactions during treatment.Conclusion Shenmai Injection has a good therapeutic effect and good safety in the treatment of gastric cancer-related fatigue with Qi and Yin deficiency.