幽门螺杆菌相关性胃炎中的细胞因子研究进展

Research progress on cytokines in Helicobacter pylori associated gastritis

幽门螺杆菌(H.pylori)是全球范围内高感染率的慢性感染性致病菌,与胃内外很多疾病的发生有关,目前H.pylori相关性胃炎(HAG)具体致病机制尚不完全清晰,部分原因与H.pylori感染后刺激体内多种细胞因子的产生有关。细胞因子在控制感染和维持慢性炎性反应的发展中起着重要作用,分析在H.pylori感染过程中的细胞因子反应是理解胃部炎性反应如何被调节的关键,并与病理和疾病结果相关。文章对参与HAG的相关细胞因子研究进展予以综述。

Helicobacter pylori is a chronic infectious pathogen with a high infection rate worldwide,which is related to the occurrence of many diseases inside and outside the stomach.Currently,the specific pathogenic mechanism of H.pylori associated gastritis(HAG)is not fully understood,and some reasons are related to the stimulation of multiple cytokines in the body after H.pylori infection.Cytokines play an important role in controlling infection and maintaining the development of chronic inflammatory response.Analyzing the cytokine response during H.pylori infection is key to understanding how gastric inflammatory response is regulated and is related to pathology and disease outcomes.The article provides a review of the research progress on cytokines involved in HAG.