生物标记物及探针在胃癌分子影像诊断中的研究进展

Progress in research of tumor biomarkers and molecular imaging probes for gastric cancer

胃癌在世界范围内仍然是一种发病率和死亡率较高的恶性肿瘤,其发病较为隐匿,发现时已经处于晚期,缺乏有效的个体化治疗方法,预后也较差.如果胃癌能够实现早期诊断,可以极大程度提高患者的生存率,然而目前传统的成像方式缺乏特异性与敏感性.近年来,分子成像技术蓬勃发展,可以在细胞和分子水平对胃癌进行非侵入性地动态监测,为临床选择治疗方案、评估疗效和预后提供更多的参考信息.本文就胃癌的生物标志物以及在各种成像模式下的分子探针做一综述.

Gastric cancer is a malignant tumor still associated with high morbidity and mortality worldwide.Its onset is relatively insidious,and when detected,it is already at an advanced stage,lacks effective individualized treatments,and has a poor prognosis.If gastric cancer can be diagnosed at an early stage,the survival rate of patients can be greatly improved.However,traditional imaging modalities lack specificity and sensitivity.In recent years,molecular imaging technology is booming,which can non-invasively and dynamically monitor gastric cancer at the cellular and molecular levels,and provide more reference information for clinical selection of treatment options and assessment of efficacy and prognosis.This article reviews the biomarkers of gastric cancer and molecular probes in various imaging modalities.©The Author(s)2024.Published by Baishideng Publishing Group Inc.All rights reserved.