动脉灌注化疗联合细胞因子诱导杀伤细胞治疗晚期卵巢癌疗效及对患者血清癌胚抗原、糖类抗原125、可溶性B7-H4蛋白水平的影响

Efficacy of arterial infusion chemotherapy combined with CIK in the treatment of advanced ovarian cancer and its effect on serum levels of carcinoembryonic antigen,carbohydrate antigen 125 and soluble B7-H4 protein

目的:探讨卵巢癌动脉灌注化疗联合细胞因子诱导的杀伤细胞(CIK)治疗晚期卵巢癌疗效及对患者血清癌胚抗原(CEA)、糖类抗原125(CA125)、可溶性B7-H4蛋白(sB7-H4)水平的影响。方法:选择103例晚期卵巢癌患者,随机分为两组,对照组(n=52)行动脉灌注化疗,观察组(n=51)行动脉灌注化疗联合CIK治疗。评价两组患者治疗效果,比较治疗前后卵巢血流参数指标搏动指数(PI)、阻力指数(RI)、收缩期峰值流速(PSV)变化及血清癌胚抗原CEA、CA125、sB7-H4水平变化,随访3年,记录两组患者3年生存率。结果:观察组总有效率88.23%高于对照组的61.54%(P<0.05)。治疗后观察组PI、RI值较对照组升高,RSV值较对照组降低(均P<0.05)。治疗后观察组血清CEA、CA125、sB7-H4水平低于对照组(均P<0.05)。观察组3年生存率为78.43%高于对照组3年生存率为57.69%(P<0.05)。结论:卵巢癌患者行髂内动脉灌注化疗联合CIK治疗是一种安全、有效的治疗手段,但对于化疗中药物的使用及剂量大小仍需进一步研究,以确定选择最优药物和制定最佳治疗方案。

Objective:To investigate the efficacy of arterial infusion chemotherapy combined with cytokine-induced killer cells(CIK)in the treatment of advanced ovarian cancer and its effects on serum levels of carcinoembryonic antigen(CEA),carbohydrate antigen 125(CA125)and soluble B7-H4 protein(sB7-H4).Methods:A total of 103 patients with advanced ovarian cancer were selected.The control group(n=52)received arterial infusion chemotherapy,and the observation group(n=51)received arterial infusion chemotherapy combined with CIK treatment.The therapeutic effects of the two groups were evaluated,and the changes of ovarian blood flow parameters such as Pulse Index(PI),Resistance Index(RI),peak systolic flow velocity(PSV)and serum carcinoembryonic antigen CEA,CA125 and sB7-H4 levels before and after treatment were compared.The 3-year survival rate of the two groups was recorded.Results:The total effective rate of observation group was 88.23%higher than 61.54%of control group(P<0.05).After treatment,the PI and RI values of the observation group were higher than those of the control group,and the RSV value was lower than that of the control group(all P<0.05).After treatment,the serum CEA,CA125 and sB7-H4 levels in observation group were lower than those in control group(all P<0.05).The 3-year survival rate was 78.43%in the observation group was higher and 57.69%in the control group(P<0.05).Conclusion:The combination of internal iliac artery infusion chemotherapy and CIK is a safe and effective treatment for ovarian cancer patients.However,the use and dosage of chemotherapy drugs need further study to determine the optimal drug selection and formulation of the best treatment plan.