KRAS、NRAS、BRAF、PIK3CA、NTRK联合检测与结直肠癌预后的相关性分析

Correlation Analysis of Combined Detection of KRAS,NRAS,BRAF,PIK3CA,and NTRK and Prognosis of Colorectal Cancer

目的探究KRAS、NRAS、BRAF、PIK3CA、NTRK联合检测与结直肠癌预后的相关性。方法回顾性纳入2017—2020年连续来本院就诊住院的结直肠癌患者100例作为研究对象,患者均进行了3年随访,以患者三年生存、病死情况等作为预后观察指标,将患者分为预后良好组与预后不良组,分析KRAS、NRAS、BRAF、PIK3CA、NTRK联合检测对结直肠癌患者预后不良的预测价值,以及KRAS、NRAS、BRAF、PIK3CA、NTRK联合检测与结直肠癌预后的相关性。结果预后不良组患者KRAS、NRAS、BRAF、PIK3CA、NTRK突变比率高于预后良好组(P<0.05)。Cox比例风险回归模型分析结果显示KRAS、NRAS、BRAF、PIK3CA、NTRK突变是结直肠癌患者预后不良的风险因素(P<0.05)。结论KRAS、NRAS、BRAF、PIK3CA、NTRK突变是结直肠癌患者预后不良的风险因素,在结直肠癌患者中对其进行检测具有重要意义,可为结直肠癌患者的早期诊断以及预后提供参考。

Objective To explore correlation of combined detection of KRAS,NRAS,BRAF,PIK3CA,and NTRK and prognosis of colorectal cancer.Methods The paper reviewed and chose 100 consecutive colorectal cancer patients in our hospital from 2017 to 2020,followed up for 3 years,and divided them into good prognosis group and poor prognosis group with prognostic indicators of 3-year survival and mortality.Predictive value of KRAS,NRAS,BRAF,PIK3CA,NTRK combined detection for poor prognosis of colorectal cancer patients,and correlation of KRAS,NRAS,BRAF,PIK3CA NTRK combined detection and prognosis of colorectal cancer was analyzed.Results Mutation rates of KRAS,NRAS,BRAF,PIK3CA,and NTRK of poor prognosis group were higher than good prognosis group(P<0.05).Cox proportional risk regression model analysis showed mutations of KRAS,NRAS,BRAF,PIK3CA,and NTRK were risk factors for poor prognosis of colorectal cancer patients(P<0.05).Conclusion Mutations of KRAS,NRAS,BRAF,PIK3CA,and NTRK are risk factors for poor prognosis of colorectal cancer patients,detection of these mutations of colorectal cancer patients is of great significance and can provide reference for early diagnosis and prognosis.