Liver-specific deficiency of TMEM30A develops spontaneous hepatocellular carcinoma

Introduction Hepatocellular carcinoma is the third leading cause of cancer deaths worldwide and mainly originates from chronic liver diseases[1].It is essential to establish a stable and effective model for studying hepatocellular carcinomas.At present,chemical induction is the most common method to establish liver cancer models in mice,in which diethylnitrosamine(DEN)and carbon tetrachloride(CCl4)are the main inducers[2].It simulates well the natural formation process of liver cancer,but the induction time is long.Human primary liver cancer organoids retain livertissue function and genetic stability[3].