摘要
Nanozymes are nanomaterials with enzyme-mimicking catalytic activity.Compared to natural enzymes,nanozymes show various properties such as easy to manufacture,stable,adjustable,and inexpensive.Nanozymes play key roles in biosensing,biocatalysis,and disease treatment.As an important kind of nanozymes,metal-organic framework(MOF)-based nanozymes are receiving a lot of attention due to their structural properties and composition.Rationally developing MOF with enzymes-like catalytic properties has opened new perspectives in biosensing.This review summarizes the up-to-date developments in synthesizing two-dimensional and three-dimensional MOF-based nanozymes and their applications in biosensing.Firstly,classification of nanozymes obtained by MOFs is categorized,and different properties of MOF-based nanozymes are described.Then,the distinctive applications of MOF-based nanozymes in identifying various analytes are thoroughly summarized.Finally,the recent challenges and progressive directions in this area are highlighted.
基金
supported by the National Key R&D Program of China(No.2022YFA1103403)
Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-D-202208)
Tsinghua-Foshan Innovation Special Fund(No.2022THFS6121)
the National Natural Science Foundation of China(No.22074157)
Postdoctoral Innovative Talent Support Program(No.BX20220160)
China Postdoctoral Science Foundation Funded Project(No.2022M711779)
Young Elite Scientist Sponsorship Program of the Beijing Association for Science and Technology(No.BYESS2023166)
Tsinghua-Peking Joint Center for Life Sciences Postdoctoral Foundation Program.
