稀土生物制造及其高附加值材料应用

Rare Earth Biological Manufacturing and High Value-added Material Application

稀土元素作为现代高精尖产业技术发展的重要原材料,被广泛应用于各个前沿领域.由于分布相对分散,稀土元素的开采常伴随着对自然环境的破坏;相似的化学性质也使稀土元素间的分离伴随着较高的能源消耗与污染排放.通过构建工程稀土微生物,可利用生物采矿技术克服传统工艺所面临的困难.此外,工程稀土微生物合成平台的建立,可实现高附加值稀土生物材料的原位合成,有效推进稀土生物材料的临床转化研究及应用.本综述对稀土微生物的理性设计、高附加值稀土生物材料的合成及其应用进行了综述,并最终对该领域的未来研究与发展提出了展望.

Rare earth elements(REEs)are widely used in various frontier fields as critical raw materials for the development of modern industries and technologies.Due to the scattered distribution,the mining of rare earth elements is often accompa-nied by damage to the natural environment;similar chemical properties also make the separation of rare earth elements with high energy consumption and severe pollution.Through the construction of engineered rare earth microorganisms,biomining technology can be employed to address the challenges encountered in traditional processes.Moreover,establishing an engi-neered rare earth microbial synthesis platform enables the in situ synthesis of high value-added rare earth biomaterials,thereby facilitating clinical translational research and application in the field of rare earth biomaterials.The rational design of rare earth microorganisms,the synthesis of high value-added rare earth biomaterials,and their applications are discussed in this review.An outlook for future research and development in this field is presented.