原发性干燥综合征患者睡眠障碍及影响因素研究进展

Research advances in sleep disturbance and related factors in patients with primary Sjögren's syndrome

原发性干燥综合征患者合并睡眠障碍患病率高,不良影响显著,治疗方式有限,且与原发疾病症状、实验室指标以及焦虑、抑郁、阻塞性呼吸暂停综合征等疾病相关。干燥综合征患者合并睡眠障碍的发病机制尚不明确,其与系统累及的相关性和治疗方式的研究很少。本文梳理和分析原发性干燥综合征合并睡眠障碍疾病的发病和治疗现状,以期加强对该疾病的认识,为临床医师早期识别该疾病提供借鉴。

Primary Sjögren's syndrome patients have a high prevalence of sleep disturbance with significant adverse effects and limited treatments,and it is associated with symptoms of the primary disease,laboratory indicators,and disorders such as anxiety,depression and obstructive sleep apnea.Its pathogenesis is still unclear.There are few researches on its correlation with systemic involvement and treatment.This article reviews the status quo of incidence and treatment of sleep disturbance in patients with primary Sjögren's syndrome,hoping to strengthen our understanding of it and provide reference for clinicians to identify this disease in the early stage.