喜炎平注射液致57例不良反应/不良事件文献分析

Literature analysis of 57 cases of adverse event/adverse drug reaction caused by Xiyanping Injection

[目的]结合喜炎平注射液临床不良反应报道,探讨其发生规律,为临床合理用药提供参考。[方法]采用文献分析方法,检索中国知网、万方数据知识服务平台、中国生物医学文献服务系统等数据库中关于喜炎平注射液不良反应的报道,对纳入研究的各相关因素进行统计分析,总结不良反应发生规律。[结果]共纳入相关文献52篇,包含不良反应/不良事件57例。分析结果发现,喜炎平注射液相关不良反应/不良事件中,尚未发现不良反应/不良事件的发生与性别、过敏史有关,不良反应/不良事件多发生于<10岁年龄组,患者原患疾病多为呼吸道感染性疾病早期,其出现时间多发生于用药后的30 min内,不良反应/不良事件主要类型为变态反应,在经过临床有效处理后,预后良好,无后遗症发生,无肝肾损伤。[结论]引起喜炎平不良反应/不良事件的可能因素众多,临床表现以变态反应为主,病情大多发展迅速,在得到及时处理后,预后良好,无肝肾损伤。

[Objective]Inspect the regularity of adverse drug reaction to Xiyanping Injection based on clinical adverse reactions reports and provide reference for clinical rational medication.[Methods]Adopts literature analysis method and searches for adverse reaction reports of Xiyanping Injection in CNKI,Wanfang,SinoMed and other databases.Analyzes the relevant factors in the studies and summarizes the occurrence regularity of adverse reactions.[Results]Total 52 related literatures are studied,including 57 adverse event/adverse drug reaction cases.The analysis results demonstrate that among Xiyanping Injection-related adverse event/adverse drug reactions medication beyond instructions cases are rarely observed.The relationship between the occurrence of adverse event/adverse drug reaction and gender or allergic history is not yet found.Adverse event/adverse drug reaction mainly occurred in the<10 years old age group,and most of the patients were in the early stage of respiratory infections.Adverse event/adverse drug reaction usually occurs in the first 30 minutes after injection.The main type of adverse event/adverse drug reaction is allergic reaction.After effective clinical treatment,adverse drug reaction has a favorable prognosis,no sequelae or liver and kidney damage.[Conclusion]There are many possible factors that may cause Xiyanping adverse event/adverse drug reaction,and the main clinical manifestation is allergic reaction.Most of the symptoms develop very fast,but after timely treatment,the prognosis is usually good and there is no liver and kidney damage.