基于数据挖掘分析蔡蔚教授辨治慢性膀胱炎的用药规律

Analysis of the Medication Rules of Professor CAI Wei in the Treatment of Chronic Cystitis Based on Data Mining

目的总结蔡蔚教授治疗慢性膀胱炎的用药规律。方法纳入2022年1月1日-2022年12月1日就诊于湖南中医药大学第一附属医院蔡蔚教授专家门诊患者,共1099诊次,建立蔡蔚教授治疗慢性膀胱炎数据库,利用中医传承计算平台(V3.0)对数据库内中药进行频次统计、中药属性统计、关联分析、K-均值聚类分析等。结果在纳入的1099首方剂中,使用频次≥100的中药共有35味,主要有甘草(1050次,95.54%)、黄芪(1030次,93.72%)、当归(969次,88.17%)等。药物四气以温性为主,其次为寒、平;五味以苦味为主,其次为甘味、辛味;归经以肝、脾经为主,其次为肺经、心经、胃经、肾经。通过关联分析及聚类分析,获取常用药物组合76个,挖掘核心处方5首。结论蔡蔚教授认为慢性膀胱炎病位在肝脾,且与肺、心、胃、肾密切相关,治法以益气活血,清热燥湿为主,寒温并用,对临床实践具有一定的指导意义。

Objective:To summarize the medication rules of Professor CAI Wei in the treatment of chronic cystitis.Methods:The outpatient who were diagnosed and treated by Professor CAI Wei in the First Affiliated Hospital of Hunan University of Chinese Medicine from January 1,2022 to December 1,2022 were included.A total of 1099 consultations were conducted and Professor CAI Wei s chronic cystitis treatment database was established.The TCM inheritance computing platform(V3.0)was used to perform the frequency statistics,property statistics,association analysis and K-mean cluster analysis of Chinese herbs in the database.Results:Among the 1099 prescriptions included,there were 35 herbs with a frequency of≥100,mainly including Licorice(1050 times,95.54%),Astragalus(1030 times,93.72%)and Angelica(969 times,88.17%).The four properties of herbs were mainly warm,followed by cold and moderate.The five tastes were mainly bitter,followed by sweet and pungent.The main channels were mainly liver and spleen,followed by lung,heart,stomach and kidney channels.Through the association analysis and cluster analysis,76 commonly used herb combinations were obtained,and 5 core prescriptions were excavated.Conclusion:Professor CAI Wei believes that chronic cystitis is located in liver and spleen,and is closely related to lung,heart,stomach and kidney.The treatment takes tonifying qi to promote blood circulation and clearing heat to dry dampness as the principal thing and combining cold and warm simultaneously,which has certain guiding significance for clinical practice.