纳米递送植物多酚防治阿尔茨海默病的研究进展

Research Progress on Nano-Delivered Plant Polyphenols in the Prevention and Treatment of Alzheimer’s Disease

阿尔茨海默病(Alzheimer’s disease,AD)是最常见的神经退行性疾病,病理机制较为复杂,随着AD发病率增加,迫切需要开发更有效的防治方法。许多研究表明植物多酚在防治神经退行性疾病方面具有巨大潜力,但是它们的生物利用度较差,在实际应用上仍存在一定的局限,利用纳米技术能够有助于植物多酚的递送。本文旨在阐述纳米递送植物多酚系统的研究进展和所面临的挑战,以及用于治疗AD的常见多酚及其作用机制。

Alzheimer’s disease(AD)is one of the most common neurodegenerative diseases with a complex pathological mechanism,and as the incidence of AD has increased recently,there is an urgent need to develop more effective prevention and treatment methods.Many studies have shown that plant polyphenols have great potential in the prevention and treatment of neurodegenerative diseases,but their bioavailability is poor,limiting their practical applications.The application of nanotechnology can be helpful for the delivery of plant polyphenols.This article aims to elaborate recent progress and challenges in the development of nano-delivery systems for plant polyphenols,and review the common plant polyphenols used for AD treatment and their action mechanisms.