摘要
金属组学与医学的交叉结合为疾病的诊断及治疗提供了新的研究方向。以肝癌为例,首先介绍了金属组学在肝癌诊断中的应用,包括常用的检测设备和诊断方法;最后介绍了金属组学在肝癌治疗中的应用,除了传统的铂类药物,还发展了钒复合物、钌复合物及砷类药物。金属组学除了用于肝癌的诊断和治疗,也可以预测疗效,如血清Zn与Fe含量的上升,Cu含量下降,提示预后较好。随着新技术的不断发展,金属组学将会在肝癌的诊断及治疗中发挥更大的价值。
The intercrossing of metallomics and medicine provides a new research direction for the diagnosis and treatment of diseases.In this review,taking liver cancer as an example,the application of metalomics in the diagnosis of liver cancer was firstly introduced,including commonly used detection measurement instruments and diagnostic methods.Finally the application of metallomics in liver cancer treatment was introduced.In addition to traditional platinum drugs,vanadium complexes,ruthenium complexes,and arsenic drugs were also been developed.In addition,metallomics can not only be used for the diagnosis and treatment of liver cancer,but also predict therapeutic effects,such as the content of Zn and Fe increased and the content of Cu decreased in serum indicated better prognosis.With the continuous development of new technologies,metallomics will play a more important role in the diagnosis and treatment of liver cancer.
作者
张艳丽
毕鹏伟
江鑫垚
王永安
蒋婷婷
王欣
李超
ZHANG Yanli;BI Pengwei;JIANG Xinyao;WANG Yongan;JIANG Tingting;WANG Xin;LI Chao(Department of Oncology,The Second Affiliated Hospital,Anhui Medical University,Hefei,Anhui 230601,China;Department of Chemistry,School of Basic Medical Sciences,Anhui Medical University,Hefei,Anhui 230032,China;The Second Clinical Medical College,Anhui Medical University,Hefei,Anhui 230000,China;The First Clinical Medical College,Anhui Medical University,Hefei,Anhui 230032,China)
出处
《中国无机分析化学》
CAS
北大核心
2024年第1期56-62,共7页
Chinese Journal of Inorganic Analytical Chemistry
基金
安徽省自然科学基金资助项目(2108085MA26)
安徽省转化医学研究所研究基金资助项目(2022zhyx-C77)
安徽医科大学临床医学专业“早期接触科研”训练计划项目(2022-ZQKY-162)
安徽医科大学校级大学生创新创业训练计划项目(X202310366060)
安徽省级临床重点专科建设项目(卫科教秘[2018]180号)。
关键词
肝癌
金属组学
诊断
治疗
liver cancer
metallomics
diagnosis
treatment
