探讨首发精神分裂症患者颅脑MRI影像学与症状的关系及临床意义

To Investigate the Relationship Between Brain MRI Imaging and Symptoms and Its Clinical Significance in Patients with First Episode Schizophrenia

目的:探究与分析首发精神分裂症患者颅脑MRI影像学与症状的关系及临床意义。方法:选取自2020年2月~2022年4月本院收治的首发精神分裂症患者56例作为观察组,选择同期收治的来本院进行体检的健康人50例作为对照组,两组人员均进行了颅脑MRI影像学检查,对比两组患者影像学检查指标;采用阳性与阴性症状量表(PANSS)对患者症状严重程度进行评价,通过采用Pearson检验,分析并探讨首发精神分裂症患者的影像学指标及临床症状的相关性。结果:观察组与对照组相比左右侧胼胝体与穹隆下方垂直距离、胼胝体与穹隆下方水平距离及脑室面积较高,差异有统计学意义(P<0.05)。行Pearson相关性分析结果可见,患者左侧紧贴胼胝体穹隆距离与阴性症状评分之间呈现出明显的正相关性(P<0.05)。结论:左右大脑在首次发作的精神分裂症患者当中多呈现出明显的不对称的情况,接近胼胝体的高度要明显高于正常人,该影像学指标与首发精神分裂症的阴性症状可呈现明显的正相关性。

Objective:To explore and analyze the relationship between craniocerebral MRI imaging and symptoms in patients with first-episode schizophrenia and its clinical significance.Methods:56 cases of first-episode schizophrenia patients admitted to our hospital from February 2020 to April 2022 were selected as the observation group,and 50 cases of healthy people admitted to our hospital for physical examination during the same period were selected as the control group.Brain MRI imaging examinations were performed in both groups,and imaging examination indexes of patients in the two groups were compared.The Positive and Negative Symptom Scale(PANSS)was used to evaluate the severity of patients’symptoms.Pearson test was used to analyze and explore the correlation between imaging indicators and clinical symptoms in patients with first-episode schizophrenia.Results:Compared with the control group,the observation group had higher vertical distance between the left and right sides of the corpus callosum and below the fornix,the horizontal distance between the corpus callosum and below the fornix and the ventricle area,and the difference was statistically significant(P<0.05).Pearson correlation analysis showed that there was a significant positive correlation between the left proximal corpus callosum dome distance and negative symptom score(P<0.05).Conclusion:The left and right brains show obvious asymmetry in patients with the first episode of schizophrenia,and the height close to the corpus callosum is significantly higher than that of normal people,and the imaging index can show a significant positive correlation with the negative symptoms of the first schizophrenia.