中医药领域应用脑-肠轴理论治疗肠易激综合征的可视化分析

Visual Analysis of Irritable Bowel Syndrome Treated with Brain-gut Axis Theory in Traditional Chinese Medicine

目的:分析中医药领域应用脑-肠轴理论治疗肠易激综合征(IBS)的现状及研究热点,阐明相关领域发展趋势,为中医药治疗IBS的临床研究及基础研究提供思路和依据。方法:检索收集国家知识基础设施数据库(CNKI)发表的中医药领域脑-肠轴理论治疗IBS的研究文献,检索时间为2000—2021年,采用CiteSpace软件对纳入文献的作者、机构、关键词进行可视化分析。结果:最终纳入符合要求的文献176篇,年发文量呈逐渐上升趋势;吴皓萌、霍清萍、储浩然、王迎寒等团队为本领域贡献最大的研究团队;南京中医药大学、广州中医药大学、山东中医药大学是发文量最多的机构;研究热点词包括“脑-肠肽”“5-羟色胺”“痛泻要方”“肝郁脾虚”等;研究内容集中于中医药疗法、实验研究及机制研究、治法方药等。结论:近20年来中医药领域脑-肠轴理论论治IBS研究取得了突出成果,目前的研究热点为总结临床经验、中医药疗法改善IBS疗效;研究趋势为调节脑-肠肽和肠道微生态。

Objective:This paper analyzed the current situation and research hotspots of brain-gut axis theory in the field of traditional Chinese medicine in the treatment of irritable bowel syndrome(IBS)and clarified the development trend of the field,so as to provide ideas and basis for the clinical and basic research of traditional Chinese medicine in the treatment of IBS.Methods:Research literature on the treatment of IBS with brain-gut axis theory in the field of traditional Chinese medicine published in the CNKI database was searched and collected.The retrieval time was from 2000 to 2021.CiteSpace software was used to visually analyze the authors,institutions,and keywords in the selected literature.Results:Finally,176 pieces of literature meeting the requirements are included,and the annual volume of publication is gradually increasing;Wu Haomeng,Huo Qingping,Chu Haoran,and Wang Yinghan are the research teams that make the greatest contribution to this field;Nanjing University of Traditional Chinese Medicine,Guangzhou University of Traditional Chinese Medicine,and Shandong University of Traditional Chinese Medicine are the institutions with the largest volume of publication.Research hot words include brain-gut peptide,5-hydroxytryptamine,Tongxie Yaofang,liver depression and spleen deficiency,etc;the research content focuses on traditional Chinese medical therapy,experimental and mechanism research,and treatment methods and prescriptions.Conclusion:In the past 20 years,the research on the treatment of IBS with brain-gut axis theory in the field of traditional Chinese medicine has made outstanding achievements.At present,the research focus is to summarize the clinical experience and improve the curative effect of IBS with traditional Chinese medical therapy.The research trend is to regulate brain-gut peptide and intestinal microecology.