血清CXCL12和CXCR7在脑梗死后血管性认知功能障碍患者中的检测价值分析

Analysis of the Detection Value of Serum CXCL12 and CXCR7 in Patients with Vascular Cognitive Impairment After Cerebral Infarction

目的探讨血清趋化因子配体12(CXCL12)和趋化因子受体7(CXCR7)在脑梗死后血管性认知功能障碍(VCI)患者中的检测价值。方法选取我院2021年2月至2023年2月收治的176例脑梗死患者作为研究组,根据有无发生VCI分为VCI组(47例)和非VCI组(129例),另选取同期在本院体检,且一般资料与研究组患者相匹配的176例健康者作为对照组。采用Spearman法分析脑梗死患者血清CXCL12、CXCR7表达水平与MoCA评分的相关性,Logistic回归分析影响脑梗死患者发生VCI的相关因素,受试者工作特征(ROC)曲线分析血清CXCL12和CXCR7对脑梗死后VCI的诊断价值。结果脑梗死患者血清CXCL12和CXCR7表达水平显著高于对照组,且VCI组二者表达水平均高于非VCI组(P<0.05);脑梗死患者血清CXCL12和CXCR7表达水平均与MoCA评分呈负相关(r=-0.857、-0.873,均P<0.05);VCI组和非VCI组年龄、临床类型比较,差异有统计学意义(P<0.05);年龄、临床类型、CXCL12、CXCR7为脑梗死患者发生VCI的危险因素(P<0.05);血清CXCL12和CXCR7单独检测诊断脑梗死后VCI的曲线下面积(AUC)分别为0.730、0.814,二者联合检测的AUC为0.871,优于单独检测(Z_(二者联合-CXCL12)=3.888、Z_(二者联合-CXCR7)=2.249,P=0.000、0.024)。结论血清CXCL12和CXCR7表达水平与脑梗死后VCI的发生密切相关,二者联合对脑梗死后VCI具有较高的诊断价值。

Objective To explore detection values of serum chemokine ligand 12(CXCL12)and chemokine receptor 7(CXCR7)in patients with vascular cognitive impairment(VCI)after cerebral infarction.Methods From February 2021 to February 2023,total 176 patients with cerebral infarction admitted to our hospital were regarded as study group,they were separated into VCI group(n=47)and non-VCI group(n=129)based on the occurrence of VCI,another 176 healthy individuals who underwent physical examination in our hospital with general information matched with patients in the study group were included as control group.Spearman method was applied to analyze correlation between serum CXCL12 and CXCR7 in patients with cerebral infarction and MoCA score.Logistic regression was applied to analyze relevant factors affecting the occurrence of VCI in patients with cerebral infarction,receiver operating characteristic(ROC)curve was applied to analyze diagnostic values of serum CXCL12 and CXCR7 for VCI after cerebral infarction.Results Serum CXCL12 and CXCR7 in patients with cerebral infarction were obviously higher than those in control group,and they in VCI group were higher than those in non-VCI group(P<0.05).Serum CXCL12 and CXCR7 in patients with cerebral infarction were negatively correlated with MoCA score(r=-0.857,-0.873,P<0.05).There was a obvious difference in age and clinical type between VCI group and non-VCI group(P<0.05).Age,clinical type,CXCL12,and CXCR7 were risk factors for VCI in patients with cerebral infarction(P<0.05).The area under the curve(AUC)of serum CXCL12 and CXCR7 for diagnosing VCI after cerebral infarction was 0.730 and 0.814,respectively.The AUC of the combined detection was 0.871,which was better than the single detection(Z_(combination-CXCL12)=3.888,Z_(combination-CXCR7)=2.249,P=0.000,0.024).Conclusion Serum CXCL12 and CXCR7 would be closely related to the occurrence of VCI after cerebral infarction,and the combination would have high diagnostic value for VCI after cerebral infarction.