睡眠相关痛性勃起发病相关风险的评估

Risk Assessment of the Onset of Sleep-related Painful Erection

【目的】睡眠相关痛性勃起(SRPE)是一种以夜间睡眠中反复被伴有疼痛的阴茎勃起中断而觉醒为临床特征的罕见睡眠障碍,目前病因尚不明确。本研究目的在于探讨可能相关的危险因素对SRPE的发病的影响。【方法】通过问卷调查的方式,我们对前来泌尿男科就诊的SRPE患者或非SRPE患者进行信息采集。通过Logistic回归分析评估年龄、职业、每晚睡眠开始时间、每周性交频率、心理状态、勃起功能障碍、慢性前列腺炎病史、前列腺增生病史、腰椎疾病史、中枢神经系统疾病史、高血压病史、糖尿病病史及家族史等是否为SRPE发病的影响因素。【结果】290名受试者完成了研究,其中对照组145名,病例组145名。单因素Logistic回归分析发现,慢性前列腺炎病史、脑力劳动、职业、中枢神经系统疾病史、晚睡、性生活频率、焦虑状态可能与SRPE发病相关。将上述因素纳入到多因素回归分析模型中后发现,性生活≥2次/周(OR 95%CI=0.326(0.179,0.592)及晚睡(24时后入睡)(OR 95%CI=0.494(0.265,0.918)可能是SRPE的保护因素;慢性前列腺炎史(OR 95%CI=3.779(2.082,6.859)可能是SRPE的危险因素。然而,中枢神经疾病史、职业影响在多因素分析中的统计学差异不显著。【结论】:慢性前列腺炎、焦虑状态可能是SRPE的独立危险因素;性生活≥2次/周及适当地推迟睡眠时间可能是独立保护因素。

【Objective】Sleep-related painful erections(SRPE)is a rare sleep disorder characterized by repeated awakening due to painful interruptions of penile erections during nighttime sleep,and its etiology is currently unclear.The purpose of this study is to explore the impact of potential risk factors on the incidence of SRPE.【Methods】Information was collected through questionnaires administered to patients who presented at the urology department and suffered from SRPE or did not suffer from SRPE.A total of 290 participants completed the study,including 145 controls and 145 cases.Logistic regression analysis was used to assess the impact of age,occupation,sleep initiation time per night,frequency of sexual intercourse per week,psychological status,erectile dysfunction,chronic prostatitis,prostate enlargement,lumbar spine disease,central nervous system disease,hypertension,diabetes and family history on the onset of SRPE.【Results】Single�factor logistic regression analysis found that a history of chronic prostatitis,intellectual labor occupation,central nervous system disease,late sleep onset,frequency of sexual activity,and anxiety status might be related to the onset of SRPE.After incorporating these factors into a multivariate regression analysis model,it was found that having sexual activity≥2 times/week(OR 95%CI=0.326(0.179,0.592)and late sleep onset(after 24:00)(OR 95%CI=0.494(0.265,0.918)might be protective factors for SRPE,while a history of chronic prostatitis(OR 95%CI=3.779(2.082,6.859)might be a risk factor for SRPE.However,there was no significant statistical difference in the impact of central nervous system diseases and occupation on multivariate analysis.【Conclusion】Chronic prostatitis and anxiety status may be independent risk factors for SRPE;having sexual activity≥2 times/week and delaying sleep time appropriately may be independent protective factors.