肺癌患者血清肿瘤标志物表达变化与临床病理特征的相关性分析

Correlation Analysis Between Changes in Serum Tumor Markers Expression and Clinical Pathological Characteristics in Lung Cancer Patients

目的探讨肿瘤标志物水平与肺癌患者临床病理特征间的关系,为临床进一步完善临床治疗提供参考。方法选取60例肺癌患者作为观察组,另选60例同期健康体检者作为对照组。所有患者均采血开展癌胚抗原(CEA)、糖类抗原153(CA153)、细胞角质蛋白19片段(CYFPA21-1)检测,比较2组间CEA、CA153、CYFPA21-1水平差异,并分析不同病理类型、TNM分期、分化程度、淋巴结转移患者间CEA、CA153、CYFPA21-1水平差异。结果观察组CEA、CA153、CYFPA21-1水平为(34.58±4.35)ng/mL、(53.84±5.37)U/mL、(10.69±1.42)ng/mL,高于对照组的(1.45±0.26)ng/mL、(10.21±1.58)U/mL、(1.36±0.22)ng/mL,差异有统计学意义(P<0.05)。TNM分期Ⅲ~Ⅳ期、低中分化、有淋巴结转移患者CEA、CA153、CYFPA21-1水平高于Ⅰ~Ⅱ期、高分化、无淋巴结转移患者,差异有统计学意义(P<0.05)。结论CEA、CA153、CYFPA21-1在肺癌中存在较高表达,且其表达与TNM分期、分化程度及淋巴结转移存在密切关系,临床可通过检测该类指标来评估肺癌病情,以开展针对性治疗,改善患者预后。

Objective To explore the relationship between the levels of tumor markers and the clinical pathological characteristics of lung cancer patients,and to provide reference for further improving clinical treatment in clinical practice.Methods 60 lung cancer patients were selected as the observation group,and another 60 healthy individuals in the same period were selected as the control group.All patients underwent blood sampling for detection of carcinoembryonic antigen(CEA),carbohydrate antigen 153(CA153),and cytokeratin 19 fragment(CYFPA21-1).The differences in CEA,CA153,and CYFPA21-1 levels between the 2 groups were compared,and the differences in CEA,CA153,and CYFPA21-1 levels between patients with different pathological types,TNM staging,differentiation,and lymph node metastasis were analyzed.Results The levels of CEA,CA153,and CYFPA21-1 in the observation group were(34.58±4.35)ng/mL,(53.84±5.37)U/mL,and(10.69±1.42)ng/mL,which were higher than those in the control group(1.45±0.26)ng/mL,(10.21±1.58)U/mL,and(1.36±0.22)ng/mL,with a statistically significant difference(P<0.05).The levels of CEA,CA153,and CYFPA21-1 in patients with TNM stageⅢ~Ⅳ,low to medium differentiation,and lymph node metastasis were higher than those in patients with stageⅠ~Ⅱ,high differentiation,and no lymph node metastasis,with statistical significance(P<0.05).Conclusion CEA,CA153,and CYFPA21-1 are highly expressed in lung cancer,and their expression is closely related to TNM staging,differentiation,and lymph node metastasis.Clinical evaluation of lung cancer condition can be achieved by detecting these indicators to carry out targeted treatment and improve patient prognosis.