摘要
目的探讨125I粒子联合经导管动脉化疗栓塞(TACE)治疗原发性肝癌的临床疗效。方法回顾性分析2018年1月至2020年12月北部战区总医院40例原发性肝癌患者的资料(男26例、女14例, 年龄41~82岁), 其中治疗组21例, 行125I粒子联合TACE治疗;对照组19例, 行TACE治疗。比较2组患者甲胎蛋白(AFP)水平, 分析2组患者的有效率、疾病控制率(DCR), 观察患者的总生存期(OS)、无进展生存期(PFS)。采用Mann-WhitneyU检验、χ^(2)检验、Kaplan-Meier法和log-rank检验分析数据。结果 125I粒子植入后2个月, 治疗组与对照组的有效率分别为76.19%(16/21)和8/19, 差异有统计学意义(χ^(2)=4.83, P=0.028);DCR分别为90.48%(19/21)和11/19(χ^(2)=4.21, P=0.040)。2组患者AFP均明显下降, 治疗组下降率大于对照组[0.87(0.84, 0.90)与0.66(0.65, 0.67);z=5.42, P<0.001]。2组患者均未发生严重不良反应。治疗组与对照组中位OS分别为18.2和10.6个月(χ^(2)=10.98, P=0.037);2组中位PFS分别为8.4和6.1个月(χ^(2)=7.54, P=0.041)。结论 125I粒子联合TACE治疗原发性肝癌可发挥协同增效作用。
Objective To explore the clinical efficacy of ^(125)I seeds implantation combined with transcatheter arterial chemoembolization(TACE)in the treatment of primary liver cancer.Methods A retrospective analysis of data from 40 patients with primary liver cancer at the Northern Theater General Hospital from January 2018 to December 2020(26 males,14 females,age 41 to 82 years)was performed.Among them,21 patients were in treatment group and underwent ^(125)I seeds implantation combined with TACE treatment,while 19 patients were in control group and received TACE treatment.Alpha-fetoprotein(AFP)levels between the two groups were compared,effective rate and disease control rate(DCR)of the two groups were analyzed,and overall survival(OS)and progression-free survival(PFS)were observed.Data were analyzed by using Mann-Whitney U test,χ^(2) test,Kaplan-Meier method and log-rank test.Results Two months after ^(125)I seeds implantation,the effective rates of treatment group and control group were 76.19%(16/21)and 8/19,respectively(χ^(2)=4.83,P=0.028);the DCRs were 90.48%(19/21)and 11/19,respectively(χ^(2)=4.21,P=0.040).AFP levels in both groups decreased significantly,with treatment group showing a greater decrease rate(0.87(0.84,0.90)and 0.66(0.65,0.67);z=5.42,P<0.001).No serious adverse reaction was observed in either group.The median OS of treatment group and control group were 18.2 and 10.6 months,respectively(χ^(2)=10.98,P=0.037);the median PFS of the two groups were 8.4 and 6.1 months,respectively(χ^(2)=7.54,P=0.041).Conclusion ^(125)I seeds implantation combined with TACE treatment can exert a synergistic and enhancing effect in the treatment of primary liver cancer.
作者
张文文
郝珊瑚
王治国
纪立秋
李根
王有超
葛香妍
张国旭
Zhang Wenwen;Hao Shanhu;Wang Zhiguo;Ji Liqiu;Li Gen;Wang Youchao;Ge Xiangyan;Zhang Guoxu(Department of Nuclear Medicine,General Hospital of Northern Theater Command,Shenyang 110016,China)
出处
《中华核医学与分子影像杂志》
CAS
CSCD
北大核心
2024年第1期16-19,共4页
Chinese Journal of Nuclear Medicine and Molecular Imaging
基金
辽宁省民生科技计划联合计划(2021JH2/10300098)。
关键词
肝肿瘤
近距离放射疗法
碘放射性同位素
化学栓塞
治疗性
肝动脉
治疗结果
Liver neoplasms
Brachytherapy
Iodine radioisotopes
Chemoembolization,therapeutic
Hepatic artery
Treatment outcome