沙门氏菌表型异质性的研究进展

Research progress on phenotypic heterogeneity of Salmonella

沙门氏菌作为一种常见的食源性致病菌,自身分化出来的子细胞因环境不同而产生差异化,使沙门氏菌在基因表达、细胞形态和生理学方面形成表型差异。这种性质会使沙门氏菌在临床上不易及时检出,容易导致临床抗菌药物治疗失败。面对抗菌药物的威胁,沙门氏菌也不断提高自身适应性和致病性。因此,为及时了解沙门氏菌在感染期间的异质性演变,深入解析沙门氏菌表型异质性的特征与机制变得至关重要。该综述主要对沙门氏菌的表型异质性研究进行了梳理,并对表型特征、机制等方面进行了简单阐述。从产生机制、宿主影响、策略体现以及基本特征方面系统地分析了异质性的存在形式以及作用。加强对沙门氏菌异质性的认识和研究,为更深一步了解异质性造成的耐药过程及发生机制提供参考。

Salmonella is a prevalent foodborne infection that divides into daughter cells in response to environmental variables,resulting in phenotypic variations in gene expression,cell shape,and physiological characteristics of it.Because of this,Salmonella may not be promptly identified in a clinical context,which can easily result in the failure of clinical antimicrobial medication treatment.As antimicrobial medications become a greater concern,Salmonella also keeps developing its own adaptability and pathogenicity.Therefore,it is essential to carefully examine the traits and causes of Salmonella phenotypic heterogeneity to quickly comprehend the evolution of Salmonella heterogeneity throughout infection.This review primarily summarizes research on the phenotypic variability of Salmonella as well as offering an in-depth overview of its characteristic characteristics and processes.In terms of generation mechanism,host influence,strategy embodiment,and fundamental characteristics,the types of heterogeneity and the roles of heterogeneity are comprehensively examined.This review provides advances in the research of Salmonella heterogeneity and a more comprehensive understanding of the mechanism behind the growth of resistance and the occurrence of heterogeneity.