八正散加减联合体外冲击波碎石术治疗直径≥1.5 cm的肾下盏结石患者的疗效

Application of modified Bazhengsan combined with extracorporeal shock wave lithotripsy in lower pole renal stone patients with diameter larger than 1.5cm

目的 探讨八正散加减联合体外冲击波碎石术(ESWL)治疗直径≥1.5 cm肾下盏结石(LPRS)患者的疗效。方法 选取直径≥1.5 cm LPRS患者82例,随机分成研究组(n=41)和对照组(n=41)。对照组给予ESWL,研究组给予八正散加减联合ESWL,比较两组疗效、症状积分、生活质量及并发症。结果 研究组总有效率高于对照组(97.56%vs.80.49%),差异有统计学意义(P<0.05);治疗后两组腰痛、血尿、尿潴留、肾绞痛症状积分均降低(t分别=45.83、30.65、59.23、44.91;27.80、20.90、39.78、32.16,P均<0.05),研究组较对照组更低(t分别=17.57、8.79、19.45、17.12,P均<0.05);治疗后两组躯体健康、社会功能、心理健康、物质生活条件等生活质量评分均提高(t分别=19.39、20.46、22.71、22.60;15.38、17.03、18.69、19.72,P均<0.05),研究组较对照组更高(t分别=4.62、3.89、4.61、4.68,P均<0.05);研究组并发症发生率低于对照组(4.88%vs.24.39%),差异有统计学意义(χ2=6.25,P<0.05)。结论 采用八正散加减联合ESWL治疗直径≥1.5 cm LPRS患者,可提高临床疗效,降低临床症状积分,改善生活质量,减少并发症。

Objective To explore the effect of Bazhengsan modified and subtracted combined with extracorporeal shock wave lithotripsy(ESWL) in lower pole renal stone(LPRS) patients with diameter ≥1.5 cm.Methods A total of82 cases LPRS patients with diameter ≥1.5cm were selected and randomely divided into the research group(41 cases)and the control group(41 cases).The control group was given ESWL,the research group was treated with modified Bazhengsan combined with ESWL.The clinical efficacy,clinical symptom scores,quality of life and complications were compared between the two groups.Results Compared with the control group,the total effective rate of treatment in the research group(97.56% vs.80.49%) was higher(P<0.05).After treatment,the symptom scores of low back pain,hematuria,urinary retention and renal colic in two groups were decreased(t=45.83,30.65,59.23,44.91,27.80,20.90,39.78,32.16,P<0.05),and the these indexes in research group were lower than the control group(t=17.57,8.79,19.45,17.12,P<0.05).After treatment,the scores of the quality of life,such as physical health,social function,mental health,material living conditions in two groups were increased(t=19.39,20.46,22.71,22.60,15.38,17.03,18.69,19.72,P<0.05),and these indexes in the research group were higher than the control group(t=4.62,3.89,4.61,4.68,P<0.05).The complication rate of the research group was lower than that of the control group(4.88% vs.24.39%),the difference was statistically significant(χ~2=6.25,P<0.05).Conclusion Bazhengsan combined with ESWL can improve the clinical efficacy,reduce the clinical symptom score,improve the quality of life and reduce the incidence of complications in LPRS patients with diameter ≥1.5cm.