摘要
糖尿病与牙周炎是由多种复杂因素引起的慢性炎症性疾病,二者联系密切,互为影响因素,均为当今社会亟待解决的重大健康问题。高糖微环境会显著加重牙周病发病率和骨丧失程度,影响牙周组织再生效果,为牙周治疗带来巨大挑战。本篇综述以牙周病的发病机制为出发点,分别介绍高糖微环境对上皮细胞、免疫细胞及干细胞等牙周组织细胞的影响,并提出相应的针对性治疗策略,为高糖微环境下的牙周治疗带来新的思路。
Diabetes and periodontitis were chronic inflammatory diseases caused by a variety of complex factors.They were closely related with each other.Both diabetes and periodontitis were urgent health problems that our society was currently grappling with.The high glucose microenvironment will significantly increase the incidence of periodontal disease and accelerate bone loss,hinder periodontal regeneration and bring great challenges to periodontal treatment.Starting from the pathogenesis of periodontal disease,this review introduced the effects of high glucose microenvironment on periodontal tissue cells such as epithelial cells,immune cells and stem cells,and proposed corresponding targeted therapeutic strategies for future periodontal treatment under high glucose microenvironment.
作者
向丹丹
贺小涛
陈发明
李璇
XIANG Dandan;HE Xiaotao;CHEN Faming;LI Xuan(Cadet Regiment,School of Basic Medical Sciences,Air Force Medical University,Xi'an 710032,China;State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,National Clinical Research Center for Oral Diseases,Shaanxi International Joint Research Center for Oral Diseases,Department of Periodontology,School of Stomatology,The Fourth Military Medical University,Xi'an 710032,China)
出处
《口腔生物医学》
2024年第1期43-48,共6页
Oral Biomedicine
基金
国家自然科学基金(82301079,82371010)
中国博士后科学基金(2022TQ0134)。
关键词
高糖微环境
牙周炎
免疫细胞
干细胞
上皮细胞
high glucose microenvironment
periodontitis
immune cells
stem cells
epithelial cell
