磷脂酰肌醇-3-激酶/蛋白激酶B与子宫内膜蜕膜化关系的研究进展

Research Progress in Correlation of Phosphatidylinositol-3-Kinase/Protein Kinase B with Endometrial Decidualization

子宫内膜蜕膜化是决定妊娠能否成功的关键因素之一。磷脂酰肌醇-3-激酶(PI3K)是哺乳动物细胞内基础信号转导通路中的主要细胞因子,在细胞的生长、增殖、凋亡、自噬、血管生成等生理和病理过程中发挥着极其重要的生物学功能。PI3K/蛋白激酶B(PKB/Akt)信号通路在细胞代谢、迁移、分化等方面影响子宫内膜蜕膜化。深入研究PI3K/Akt在子宫内膜蜕膜化中的作用,可为蜕膜化缺陷相关疾病的诊断和治疗提供新思路,对更好地指导临床、提高妊娠成功率具有重要意义。

Endometrial decidualization is one of the key factors determining the success of pregnancy.Phosphatidylinositol-3-kinase(PI3K)is a major cytokine in the basic signaling pathways in mammalian cells,and plays an extremely important biological role in various physiological and pathological processes such as cell growth,proliferation,apoptosis,autophagy and angiogenesis.PI3K/protein kinase B(PKB/Akt)signaling pathway affects endometrial decidualization in various aspects such as cell metabolism,migration and differentiation,etc.In-depth study of the role of PI3K/Akt in endometrial decidualization provides new ideas for the diagnosis and treatment of decidualization-defective related diseases,which is of great significance for better guiding the clinical practice and improving pregnancy success rate.