BALF-mNGS在难治性肺炎支原体肺炎中的应用1例

One case of the application of BALF-mNGS in refractory mycoplasma pneumoniae pneumonia

难治性肺炎支原体肺炎(RMPP)是肺炎支原体感染的一种严重状态。该病以发热持续时间长、住院时间长和易出现肺外并发症为特点。本文收治1例快速进展的肺炎支原体肺炎患儿,怀疑合并肺炎克雷伯菌感染。通过宏基因组二代测序(mNGS)确诊,使用头孢哌酮舒巴坦联合米诺环素抗感染及纤维支气管镜下肺泡灌洗治疗后,病情转归良好。病原mNGS在病原学混合感染诊断中具有重要的意义,对于RMPP患者,积极早期应用纤维支气管镜下肺泡灌洗治疗,可以明确诊断同时获得良好的治疗效果。

Refractory mycoplasma pneumoniae pneumonia(RMPP)is a serious condition of mycoplasma pneumoniae infection,characterized by a long duration of fever,prolonged hospital stay,and susceptibility to extrapulmonary complications.A case of rapidly progressing mycoplasma pneumoniae pneumonia in a child was included in this article.It was suspected to be associated with Klebsiella pneumoniae infection,which was then confirmed by metagenomic next-generation sequencing(mNGS).Cefoperazone sulbactam combined with minocycline is used for anti-infection and broncho-fiberscope alveolar lavage treatment,with a good prognosis.The mNGS of the pathogen is of great significance in the diagnosis of coinfections in etiology.For RMPP patients,it is necessary to actively apply early bronchoalveolar lavage under fiberoptic bronchoscopy,which can provide a clear diagnosis and achieve good therapeutic results.