卡前列素氨丁三醇治疗宫缩乏力性产后出血效果分析

Analysis of the effect of carprost tramine in the treatment of postpartum hemorrhage caused by uterine fatigue

目的探讨宫缩乏力性产后出血采用卡前列素氨丁三醇治疗的效果。方法选择50例宫缩乏力性产后出血患者为研究对象,按照随机数字表法分为对照组和研究组,每组25例。对照组给予缩宫素治疗,研究组给予卡前列素氨丁三醇治疗,比较两组治疗效果、出血情况、凝血功能指标、血红蛋白水平、不良反应情况。结果治疗后,研究组总有效率高于对照组(P<0.05);产后2h、产后24h,研究组出血量均少于对照组(P<0.05);产后2h,两组血红蛋白水平比较差异无统计学意义(P>0.05);产后24h,研究组血红蛋白低于对照组(P<0.05);分娩前和分娩后24h,两组凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血酶时间(APTT)和纤维蛋白原(FIB)比较,差异均无统计学意义(P>0.05);治疗后,两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论宫缩乏力性产后出血采用卡前列素氨丁三醇治疗效果较好,可减少出血量,降低血红蛋白水平,还可减少对凝血功能的影响,且用药安全性较高,值得临床推广与应用。

Objective To investigate the effect of carprost triol in the treatment of postpartum hemorrhage caused by uterine fatigue.Methods 50 patients with postpartum hemorrhage due to uterine fatigue were selected as the study objects and divided into control group and study group according to random number table,with 25 cases in each group.The control group was given oxytocin treatment,and the study group was given carprost tropanol treatment.The therapeutic effect,bleeding,coagulation function index,hemoglobin level and adverse reactions of the two groups were compared.Results After treatment,the total effective rate of the study group was higher than that of the control group(P<0.05).2h and 24h postpartum,the blood loss in the study group was less than that in the control group(P<o.05).Two hours after delivery,there was no significant difference in hemoglobin level between the two groups(P>0.05).24h after delivery,hemoglobin in the study group was lower than that in the control group(P<0.05).There was no significant difference in prothrombin time(PT),thrombin time(TT),activated partial thrombin time(APTT),and fibrinogen(FIB)between the two groups before delivery and 24h after delivery(P>0.05).After treatment,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment of postpartum hemorrhage with caprost tramine is effective,which can reduce the amount of blood loss,reduce the level of hemoglobin,and reduce the influence on coagulation function,and the drug is safe,worthy of clinical promotion and application.