CO_(2)点阵激光联合超分子水杨酸在治疗痤疮凹陷性瘢痕中的疗效和安全性

Efficacy and Safety of CO_(2) Lattice Laser Combined with Supramolecular Salicylic Acid in the Treatment of Acne Concave Scars

目的探讨CO_(2)点阵激光联合超分子水杨酸在治疗痤疮凹陷性瘢痕中的疗效和安全性。方法将116例痤疮凹陷性瘢痕患者随机分为两组,对照组单用CO_(2)点阵激光治疗,观察组使用CO_(2)点阵激光联超分子水杨酸治疗,对比两组的临床疗效、皮肤屏障功能指标、VAS疼痛评分及ECCA评分、各项治疗指标。结果观察组治疗有效率为89.66%,明显高于对照组的65.52%(P<0.05);观察组治疗后经皮水分散失、红斑值、黑素值、pH均低于对照组,角质层含水量高于对照组(P<0.05),两组油脂相当(P>0.05);观察组治疗后VAS疼痛评分、ECCA评分明显低于对照组(P<0.05);观察组结痂时间、痂皮脱落时间明显短于对照组(P<0.05),两组皮肤轻微刺痛、轻微瘙痒等不良反应相当(P>0.05)。结论CO_(2)点阵激光联超分子水杨酸在治疗痤疮凹陷性瘢痕中的疗效显著,能有效改善皮肤屏障功能,促进凹陷性瘢痕消退,加快结痂及脱痂时间,且不良反应发生率低。

Objective To investigate the efficacy and safety of CO_(2) dot matrix laser combined with supramolecular salicylic acid in the treatment of acne scar.Methods 116 patients with acne concave scarwere randomly divided into two groups.The control group was treated with CO_(2) dot matrix laser alone,and the observation group was treated with CO_(2) dot matrix laser combined with supramolecular salicylic acid.The clinical efficacy,skin barrier function index,VAS pain score,ECCA score,and various treatment indexes of the two groups were compared.Results The effective rate of observation group was 89.66%,which was significantly higher than that of control group(65.52%,P<0.05);After treatment,the skin water loss,erythema value,melanin value and pH value in the observation group were lower than those in the control group,and the water content in the stratum corneum was higher than that in the control group(P;After treatment,VAS pain score and ECCA score in the observation group were significantly lower than those in the control group(P<0.05);The time of scab formation and scab peeling off in the observation group was significantly shorter than that in the control group(P>0.05).Conclusion The effect of CO_(2) dot matrix laser combined with supramolecular salicylic acid in the treatment of acne scar depression is significant,which can effectively improve the skin barrier function,promote the regression of acne scar depression,accelerate the time of scab formation and scab removal,and the incidence of adverse reactions is low.