参附注射液辅助治疗失血性休克对患者生命体征及血流动力的影响

Effects of Shenfu injection as an adjuvant treatment for hemorrhagic shock on vital signs and hemodynamics of patients

目的观察参附注射液辅助治疗妇科急性失血性休克对患者生命体征及血流动力的影响。方法回顾性收集2020年1月~2023年3月期间本院诊治的50例妇科急性失血性休克患者的临床资料,根据是否采用参附注射液辅助治疗分为对照组25例和观察组25例。对照组给予早期液体复苏治疗,观察组在对照组的基础上给予参附注射液辅助治疗,两组均连续治疗48h。记录两组治疗前(T0)、治疗12h(T1)、治疗24h(T2)、治疗48h(T3)生命体征[收缩压(SBP)、舒张压(DBP)、心率(HR)]、脑氧代谢指标(脑动脉-静脉血氧含量差和颈静脉球血氧饱和度)、脑血流动力学参数[脑中动脉收缩期血流速度(Vp)、舒张期血流速度(Vd)、阻力指数(RI)、搏动指数(PI)]及住院期间预后情况[多器官综合征(MODS)、急性呼吸窘迫综合征(ARDS)、病死情况]。结果两组T0时生命体征、脑氧代谢指标及血流动力比较无明显差异(P>0.05);T1~T3时,观察组SBP、DBP明显高于对照组,HR显著低于对照组(P<0.05);且脑动脉-静脉血氧含量差显著低于对照组,颈静脉球血氧饱和度显著高于对照组(P<0.05);Vp、Vd显著高于对照组,RI、PI显著低于对照组(P<0.05)。两组患者MODS、ARDS发生率以及病死率差异无统计学意义(P>0.05)。结论参附注射液辅助治疗妇科急性失血性休克患者,能迅速恢复血流动力学稳定,改善微循环和组织代谢。

Objective Objective:To observe the effect of Shenfu Injection on the vital sig-ns and hemodynamics of patients with gynecological acute hemorrhagic shock.Methods Clinical data of 50 patients with gynecological acute hemorrhagic shock treated in our hospital from January 2020 to March 2023 were retrospectively collected.They were divided into a control group of 25 cases and an observation group of 25 cases based on whether Shenfu injection was used as an adjuvant treatment.The control group received early fluid resuscitation treatment,while the observation group received auxiliary treatment with Shenfu Injection on the basis of the control group.Both groups received continuous treatment for 48 hours.Record the vital signs systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR)J,cerebral oxygen metabolism indicators(cerebral arterial venous oxygen content difference and jugular bulb oxygen saturation)before treatment(T_(0)),12 hours(T_(1)),24 hours(T_(2)),and 48 hours(T_(3))in two groups Cerebral hemodynamic parameters[systolic blood flow velocity(Vp),diastolic blood flow velocity(Vd),resistance index(RI),pulsatile index(PI)and prognosis during hospitalization[multiple organ syndrome(MODS),acute respiratory distress syndrome(ARDS),and mortality status].Results There was no significant difference in vital signs,cerebral oxygen metabolism indicators,and hemodynamics between the two groups at TO(P>O.05);At T1~T3,SBP and DBP in the observation group were significantly higher than those in the control group,while HR was significantly lower than that in the control group(P<O.05);And the difference in cerebral arterial venous oxygen content was significantly lower than the control group,while the jugular bulb oxygen saturation was significantly higher than the control group(P<0.05);Vp and Vd were significantly higher than the control group,while RI and PI were significantly lower than the control group(P<0.05).There was no statistically significant difference in the incidence and mortality of MODS,ARDS between the two groups of patients(P>0.05).Conclusions Shenfu Injection can quickly restore hemodynamic stability,improve microcirculation and tissue metabolism in patients with acute hemorrhagic shock in gynecology.