线粒体自噬在肝脏相关疾病发生发展中的作用

Role of mitophagy in the development and progression of liver-related diseases

线粒体自噬是细胞在营养缺乏或受到外界刺激时,通过对受损线粒体的特异性清除,来维持线粒体功能完整性和细胞稳态的选择性自噬。近年来,大量研究证明线粒体自噬功能失调与非酒精性脂肪性肝病、药物性肝损伤、病毒性肝炎和肝细胞癌等多种肝脏相关疾病的发生发展密切相关。本文通过对线粒体自噬调控肝脏相关疾病的具体机制进行总结,进一步阐述了线粒体自噬在肝脏相关疾病中的潜在治疗靶点,以期为肝病的临床治疗提供更为有效的策略。

Mitophagy is a type of selective autophagy during which cells specifically remove damaged mitochondria in response to nutrient deficiency or external stimulation and thus maintain the integrity of mitochondrial function and cellular homeostasis.In recent years,a large number of studies have shown that dysfunction of mitophagy is closely associated with the development and progression of various liver-related diseases such as nonalcoholic fatty liver disease,drug-related liver injury,viral hepatitis,and hepatocellular carcinoma.This article summarizes the specific mechanisms of mitophagy in regulating liver-related diseases and further elaborates on the potential therapeutic targets of mitophagy in liver-related diseases,in order to provide more effective therapeutic strategies for the clinical treatment of liver diseases.